DT A:B binds HBEGF and CD9 on the target cell surface

Stable Identifier
R-HSA-5336417
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Corynephage beta
Compartment
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Diphtheria toxin fragments A and B, linked by a disulfide bond (DT A:B) (Collier and Kandel 1971; DeLange et al. 1979; Lambotte et al. 1980; Michel et al. 1972) bind to molecules of proheparin-binding EGF-like growth factor (HBEGF) and CD9 antigen on the target cell plasma membrane. While binding to HBEGF is sufficient for DT A:B uptake into a target cell, presence of CD9 on the target cell surface substantially increases its sensitivity to DT and cross-linking and immunopreciptitation studies indicate that DT A:B, HBEGF, and CD9 form a complex on the cell surface (Brown et al. 1993; Iwamoto et al. 1994). The organization and order of assembly of the complex are not known.

Participants
Participant Of
Disease
Name Identifier Synonyms
diphtheria 11405 corynebacterium infection
Authored
Reviewed
Created