Reactome | COX6A2 [mitochondrial inner membrane]

COX6A2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5336146

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Cytochrome c oxidase subunit 6A2, mitochondrial, CX6A2_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - CO binds to Cytochrome c oxidase (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A:PE [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A1,2 [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A2 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A:PE [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A1,2 [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A2 [mitochondrial inner membrane] (Homo sapiens)
      - Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A:PE [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A1,2 [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A2 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A:PE [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A1,2 [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A2 [mitochondrial inner membrane] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A:PE [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A1,2 [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A2 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A:PE [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A1,2 [mitochondrial inner membrane] (Homo sapiens)
        
        COX6A2 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02221 COX6A2

Gene Names

COX6A2, COX6A, COX6AH

Chain

transit peptide:1-12, chain:13-97

Reference Genes

BioGPS Gene:1339 COX6A2

COSMIC (genes):COX6A2 COX6A2

CTD Gene:1339 COX6A2

dbSNP Gene:1339 COX6A2

ENSEMBL:ENSG00000156885 COX6A2

HGNC:2279 COX6A2

KEGG:hsa:1339 COX6A2

Monarch:1339 COX6A2

NCBI Gene:1339 COX6A2

OMIM:602009 COX6A2

UCSC:Q02221 COX6A2

Reference Transcript

RefSeq:NM_005205.3 COX6A2

Other Identifiers

11722364_at

1339

16826010

206353_PM_at

206353_at

3688364

3688365

3688366

3688367

3688368

3688369

3688370

3688371

38660_at

8001041

A_23_P49424

A_33_P3279610

GE551482

GE61817

GO:0003824

GO:0005739

GO:0005743

GO:0005751

GO:0006091

GO:0006119

GO:0006123

GO:0016491

GO:0030234

GO:0043226

GO:0045277

GO:0098772

HMNXSV003045378

ILMN_1752481

M83308_at

TC16001055.hg

g4885148_3p_at

Participates

as a member of

COX6A1,2 [mitochondrial inner membrane] (Homo sapiens)

Inferred To

levy [mitochondrial inner membrane] (Drosophila melanogaster)

COX6AL [mitochondrial inner membrane] (Drosophila melanogaster)

COX6AL2 [mitochondrial inner membrane] (Drosophila melanogaster)

cox6a2 [mitochondrial inner membrane] (Danio rerio)

COX6A2 [mitochondrial inner membrane] (Bos taurus)

COX6A2 [mitochondrial inner membrane] (Canis familiaris)

COX6A2 [mitochondrial inner membrane] (Gallus gallus)

COX6A2 [mitochondrial inner membrane] (Sus scrofa)

Homologues of COX6A2 [mitochondrial inner membrane] (Drosophila melanogaster)

Cox6a2 [mitochondrial inner membrane] (Mus musculus)

Cox6a2 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000287490, ENSP00000287490, ENSG00000156885

OpenTargets

ENSG00000156885

GeneCards

COX6A2

HPA

ENSG00000156885-COX6A2

PRO

Q02221

Pharos - Targets

Q02221

HMDB Protein

HMDBP03145