UHRF1:Chromatin binds DNMT1

Stable Identifier
Reaction [binding]
Homo sapiens
UHRF1 recruits DNMT1
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As inferred from the mouse homolog, UHRF1 associates with hemimethylated DNA and histone H3 tails methylated at lysine-9. UHRF1 recruits and tethers DNMT1 (Bostick et al. 2007). The association of UHRF1 with DNMT1 occurs preferentially during S-phase when DNA is hemimethylated as the newly replicated strand remains transiently unmethylated (Zhang et al. 2011, Hervouet et al. 2012). DNMT1 also forms complexes with transcription factors such as TP53 (p53) and YY1 at other times during the cell cycle (Hervouet et al. 2012).

Literature References
PubMed ID Title Journal Year
22064703 S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance

Li, J, Koseki, H, Wu, W, Li, P, Zhang, J, Dong, S, Liu, X, Gao, Q, Jia, Y, Wong, J

Cell Res. 2011
22348533 Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle

Vallette, FM, Hervouet, E, Cartron, PF, Nadaradjane, A, Gueguen, M

Cell Div 2012
17673620 UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Pradhan, S, Clark, A, Jacobsen, SE, Bostick, M, Kim, JK, Estève, PO

Science 2007
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