Reactome | DNMT3L [nucleoplasm]

DNMT3L [nucleoplasm]

Stable Identifier

R-HSA-5334123

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA, DNM3L_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UJW3 DNMT3L

Gene Names

DNMT3L

Chain

chain:1-386

Reference Genes

BioGPS Gene:29947 DNMT3L

COSMIC (genes):DNMT3L DNMT3L

CTD Gene:29947 DNMT3L

dbSNP Gene:29947 DNMT3L

ENSEMBL:ENSG00000142182 DNMT3L

HGNC:2980 DNMT3L

KEGG:hsa:29947 DNMT3L

Monarch:29947 DNMT3L

NCBI Gene:29947 DNMT3L

OMIM:606588 DNMT3L

UCSC:Q9UJW3 DNMT3L

Reference Transcript

Participates

as an input of

PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex (Homo sapiens)

as a component of

Cross References

OpenTargets

ENSG00000142182

ENSEMBL

ENSP00000486001, ENST00000628202, ENSP00000270172, ENST00000270172, ENSG00000142182

HPA

ENSG00000142182-DNMT3L

GeneCards

DNMT3L

PRO

Q9UJW3

Pharos - Targets

Q9UJW3

GlyGen

Q9UJW3

HMDB Protein

HMDBP09943

PDB

6U8W, 6U8X, 8XEE, 8TCI, 2PVC, 4U7T, 7X9D, 5YX2, 6KDT, 4U7P, 6U8V, 2PV0, 6U90, 6U91, 6U8P, 6BRR, 6KDP, 6KDA, 6KDB, 6W8D, 6W8B, 6W8J, 6F57, 2QRV, 6KDL, 6W89

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHA3 RLP24			0.781	7
UniProt:Q17RL8 Q17RL8			0.556	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.544	3