Reactome | TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes

TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes

Stable Identifier

R-HSA-5334050

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes

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In addition to repressing WNT-dependent targets through Groucho/TLE proteins, some TCF/LEF transcription factors may also work by recruiting the CTBP1 and CTBP2 repressors (Duval et al, 2000). CTBP-binding regions are present in the 'E-form' splice variants of TCF7L2 and in TCF7L1 and in vitro interactions have been demonstrated in Xenopus and mammals, although the in vivo relevance of these interactions is unclear (Brannon et al, 1999; Valenta et al, 2003; Cuilliere-Dartigues et al, 2006; Tang et al, 2008; Hamada and Bienz, 2004). Abrogation of the interaction interface results in a loss of TCF-CTBP colocalization and increased expression of a TCF-dependent reporter gene (Cuilliere-Dartigues et al, 2006; Tang et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
12711682	HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells Valenta, T, Lukas, J, Korinek, V	Nucleic Acids Res.	2003
10375506	XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development Brannon, M, Brown, JD, Bates, R, Kimelman, D, Moon, RT	Development	1999
10919662	The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines Duval, A, Rolland, S, Tubacher, E, Bui, H, Thomas, G, Hamelin, R	Cancer Res.	2000
16547505	TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription Cuilliere-Dartigues, P, El-Bchiri, J, Krimi, A, Buhard, O, Fontanges, P, Fléjou, JF, Hamelin, R, Duval, A	Oncogene	2006
18621708	A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer Tang, W, Dodge, M, Gundapaneni, D, Michnoff, C, Roth, M, Lum, L	Proc. Natl. Acad. Sci. U.S.A.	2008
15525529	The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF Hamada, F, Bienz, M	Dev. Cell	2004