TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes

Stable Identifier
R-HSA-5334050
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In addition to repressing WNT-dependent targets through Groucho/TLE proteins, some TCF/LEF transcription factors may also work by recruiting the CTBP1 and CTBP2 repressors (Duval et al, 2000). CTBP-binding regions are present in the 'E-form' splice variants of TCF7L2 and in TCF7L1 and in vitro interactions have been demonstrated in Xenopus and mammals, although the in vivo relevance of these interactions is unclear (Brannon et al, 1999; Valenta et al, 2003; Cuilliere-Dartigues et al, 2006; Tang et al, 2008; Hamada and Bienz, 2004). Abrogation of the interaction interface results in a loss of TCF-CTBP colocalization and increased expression of a TCF-dependent reporter gene (Cuilliere-Dartigues et al, 2006; Tang et al, 2008).

Literature References
PubMed ID Title Journal Year
12711682 HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells

Valenta, T, Lukas, J, Korinek, V

Nucleic Acids Res. 2003
10375506 XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development

Brannon, M, Brown, JD, Bates, R, Kimelman, D, Moon, RT

Development 1999
10919662 The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines

Duval, A, Rolland, S, Tubacher, E, Bui, H, Thomas, G, Hamelin, R

Cancer Res. 2000
16547505 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription

Cuilliere-Dartigues, P, El-Bchiri, J, Krimi, A, Buhard, O, Fontanges, P, Fléjou, JF, Hamelin, R, Duval, A

Oncogene 2006
18621708 A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

Tang, W, Dodge, M, Gundapaneni, D, Michnoff, C, Roth, M, Lum, L

Proc. Natl. Acad. Sci. U.S.A. 2008
15525529 The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF

Hamada, F, Bienz, M

Dev. Cell 2004
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