Reactome | CLAT:AP1:CLVS bind PI(3,5)P2

CLAT:AP1:CLVS bind PI(3,5)P2

Stable Identifier

R-HSA-5333658

Type

Reaction [binding]

Species

Homo sapiens

Compartment

trans-Golgi network membrane, lysosomal membrane, clathrin-coated endocytic vesicle membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Clathrin-coated vesicles (CCVs) originating from the trans-Golgi network (TGN) provide a major transport pathway from the secretory system to endosomes/lysosomes. Clavesin 1 and 2 (CLVS1 and 2) are enriched on CCVs and form a complex with clathrin heavy chain (CHC) and adaptor protein-1 (AP1) complex, major coat components of TGN-derived CCVs. The complex can bind phosphatidylinositol 3,5-bisphosphate (PIP2), a phospholipid localised to late endosomes and lysosomes. This interaction is thought to assist the transport of cytosolic cargo proteins to the endosomal network (Katoh et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19651769	The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology Blondeau, F, Höning, S, Katoh, Y, Ritter, B, McPherson, PS, Gaffry, T	J. Biol. Chem.	2009