GSSebGalNac is reduced and methylated to MeSebGalNac

Stable Identifier
R-HSA-5333608
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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GSSebGalNac is reduced and methylated to MeSebGalNac
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1beta-glutathionylseleno-N-acetyl-D-galactosamine (GSSebGalNac) aka selenosugar A is converted into 1beta-methylseleno-N-acetyl-D-galactosamine (MeSebGalNac) aka selenosugar B by an unknown mechanism. The actual enzyme or enzymes involved have yet to be identified. This reaction is inferred from the event in rat (Kobayashi et al. 2002).
Literature References
PubMed ID Title Journal Year
12441402 Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range

Kobayashi, Y, Ogra, Y, Ishiwata, K, Takayama, H, Aimi, N, Suzuki, KT

Proc. Natl. Acad. Sci. U.S.A. 2002
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Catalyst Activity

methyltransferase activity of unknown selenosugar methylase [cytosol]

Physical Entity
unknown selenosugar methylase [cytosol] (Homo sapiens)
Activity
methyltransferase activity (GO:0008168)
Inferred From
GSSebGalNac is reduced and methylated to MeSebGalNac (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Hill, DP  (2025-02-25)
Created
Williams, MG  (2014-02-19)
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