Under non-stress conditions monomeric HSF1 is sequestered in a HSP90-containing heterocomplex. FKBP4 (immunophilin) is one of the components of HSP90-chaperone machinery which was found to associate with trimeric, but not monomeric form of HSF1 (Guo Y et al. 2001). Multichaperone complex of HSP90:FKBP4:PKGES3 has been shown to associate with HSF1 trimer through its regulatory domain, and this is thought to repress HSF1 transcriptional activity (Guo Y et al. 2001).
Voellmy, R, Pratt, WB, Smith, DF, Toft, DO, Guettouche, T, Guo, Y, Fenna, M, Boellmann, F
Hjermstad, S, Rimerman, RA, Smith, DF, Nair, SC, Toran, EJ, Smithgall, TE
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