Reactome | ADCY1 [plasma membrane]

ADCY1 [plasma membrane]

Stable Identifier

R-HSA-53231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenylate cyclase, type 1, ATP pyrophosphate-lyase, Ca(2+)/calmodulin activated adenylyl cyclase

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
      - G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Adenylate cyclase produces cAMP (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)
        
        ADCY1,ADCY8 [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        ADCY1,ADCY8:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        ADCY1,ADCY8 [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)
        
        ADCY1,ADCY8:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        ADCY1,ADCY8 [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q08828 ADCY1

Gene Names

ADCY1

Chain

chain:1-1119

Reference Genes

BioGPS Gene:107 ADCY1

COSMIC (genes):ADCY1 ADCY1

CTD Gene:107 ADCY1

dbSNP Gene:107 ADCY1

ENSEMBL:ENSG00000164742 ADCY1

HGNC:232 ADCY1

KEGG:hsa:107 ADCY1

Monarch:107 ADCY1

NCBI Gene:107 ADCY1

OMIM:103072 ADCY1

UCSC:Q08828 ADCY1

Reference Transcript

RefSeq:NM_021116.2 ADCY1

Other Identifiers

107

11722266_at

17045806

213245_PM_at

213245_at

215348_PM_at

215348_at

232062_PM_at

232062_at

235049_PM_at

235049_at

239076_PM_at

239076_at

3000351

3000352

3000353

3000354

3000355

3000356

3000357

3000358

3000364

3000369

3000371

3000376

3000377

3000381

3000384

3000385

3000388

3000392

3000393

3000395

3000396

3000397

3000398

3000399

3000400

3000401

3000402

3000408

3000409

3000410

3000411

3000412

3000416

3000417

3000418

3000419

3000420

3000421

3000422

3000423

3000424

3000425

3000426

3000433

33353_at

35580_at

61740_at

67169_at

73724_f_at

73726_r_at

8132667

A_14_P127469

A_14_P132820

A_14_P201667

A_23_P21002

GE61020

GE88405

GO:0003824

GO:0004016

GO:0005516

GO:0005524

GO:0005737

GO:0005886

GO:0006171

GO:0006355

GO:0006954

GO:0007189

GO:0007409

GO:0007616

GO:0007623

GO:0008294

GO:0009190

GO:0009410

GO:0009975

GO:0014069

GO:0016020

GO:0016829

GO:0016849

GO:0019933

GO:0032793

GO:0035556

GO:0042752

GO:0043226

GO:0045121

GO:0046872

GO:0048511

GO:0050804

GO:0050877

GO:0055086

GO:0070062

GO:0071277

GO:0098685

GO:0098686

GO:0098793

GO:0098839

GO:0098978

GO:0099171

GO:0150076

GO:1900273

GO:1901135

GO:1904322

HMNXSV003005837

HMNXSV003010754

HMNXSV003041127

Hs.122817.0.A1_3p_at

Hs.259768.0.S1_3p_at

Hs.259768.0.S1_3p_x_at

Hs.271920.0.S1_3p_at

Hs.271920.0.S1_3p_x_at

Hs.282846.0.S1_3p_at

Hs.301663.0.A1_3p_at

ILMN_1742073

ILMN_2120555

L05500_at

PH_hs_0023305

TC07000283.hg

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Homo sapiens)

as a member of

Inferred To

acy-3 [plasma membrane] (Caenorhabditis elegans)

ADCY1 [plasma membrane] (Bos taurus)

ADCY1 [plasma membrane] (Canis familiaris)

ADCY1 [plasma membrane] (Danio rerio)

ADCY1 [plasma membrane] (Dictyostelium discoideum)

ADCY1 [plasma membrane] (Drosophila melanogaster)

ADCY1 [plasma membrane] (Gallus gallus)

ADCY1 [plasma membrane] (Mus musculus)

ADCY1 [plasma membrane] (Rattus norvegicus)

ADCY1 [plasma membrane] (Sus scrofa)

ADCY1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_066939.1

Guide to Pharmacology - Targets

1278

ENSEMBL

ENST00000297323, ENSP00000297323, ENSG00000164742

OpenTargets

ENSG00000164742

ZINC - Substances

ADCY1_HUMAN

ZINC - Biogenic

ADCY1_HUMAN

ZINC target

Q08828

PRO

Q08828

GlyGen

Q08828

ZINC - Investigational

ADCY1_HUMAN

ZINC - Metabolites

ADCY1_HUMAN

GeneCards

ADCY1

HPA

ENSG00000164742-ADCY1

Pharos - Targets

Q08828

Orphanet

ADCY1

ZINC - Predictions - Purchasable

ADCY1_HUMAN

HMDB Protein

HMDBP00711

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