Reactome | ANXA1 [cytosol]

ANXA1 [cytosol]

Stable Identifier

R-HSA-5263630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Annexin A1, ANXA1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96EF9 ZHX1R

Expand all

External Reference Information

External Reference

UniProt:P04083 ANXA1

Gene Names

ANXA1, ANX1, LPC1

Chain

initiator methionine:, chain:2-346, peptide:2-26

Reference Genes

BioGPS Gene:301 ANXA1

COSMIC (genes):ANXA1 ANXA1

CTD Gene:301 ANXA1

dbSNP Gene:301 ANXA1

ENSEMBL:ENSG00000135046 ANXA1

ENSEMBL_homo_sapiens_GENE:ENSG00000135046.14 ANXA1

HGNC:533 ANXA1

KEGG Gene (Homo sapiens):301 ANXA1

Monarch:301 ANXA1

NCBI Gene:301 ANXA1

OMIM:151690 ANXA1

Reference Transcript

Other Identifiers

11717514_a_at

11744953_a_at

11744954_x_at

11744955_a_at

17085901

201012_PM_at

201012_at

301

3174821

3174828

3174829

3174830

3174831

3174832

3174834

3174835

3174836

3174838

3174840

3174845

3174847

3174850

3174853

3174856

3174857

37403_at

8155849

A_14_P122797

A_23_P94501

GE59671

GO:0000278

GO:0001533

GO:0001780

GO:0001891

GO:0002250

GO:0002376

GO:0002548

GO:0002685

GO:0004859

GO:0005102

GO:0005509

GO:0005515

GO:0005543

GO:0005544

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005912

GO:0005925

GO:0005929

GO:0006629

GO:0006909

GO:0006954

GO:0007010

GO:0007155

GO:0007165

GO:0007166

GO:0007187

GO:0008289

GO:0008360

GO:0009986

GO:0010008

GO:0010165

GO:0012501

GO:0014839

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0016328

GO:0018149

GO:0019834

GO:0022414

GO:0023052

GO:0030036

GO:0030073

GO:0030154

GO:0030216

GO:0030312

GO:0030659

GO:0030850

GO:0031012

GO:0031018

GO:0031340

GO:0031394

GO:0031410

GO:0031514

GO:0031901

GO:0031982

GO:0032355

GO:0032508

GO:0032652

GO:0032717

GO:0032743

GO:0033031

GO:0035924

GO:0036211

GO:0042060

GO:0042063

GO:0042102

GO:0042119

GO:0042127

GO:0042383

GO:0042995

GO:0043066

GO:0043226

GO:0043227

GO:0043434

GO:0045087

GO:0045627

GO:0045629

GO:0045920

GO:0046632

GO:0046872

GO:0046883

GO:0048306

GO:0048856

GO:0048870

GO:0050482

GO:0050727

GO:0051179

GO:0061024

GO:0062023

GO:0070062

GO:0070301

GO:0070365

GO:0070459

GO:0070555

GO:0071385

GO:0071621

GO:0090050

GO:0090303

GO:0097350

GO:0098542

GO:0098609

GO:0098631

GO:0098641

GO:0098772

GO:1900087

HMNXSV003032171

ILMN_2184184

PH_hs_0023492

TC09000335.hg

X05908_at

g4502100_3p_s_at

Participates

as a component of

CAV3:TRIM72:DYSF:ANXA6:ANXA1:ANXA2 [plasma membrane] (Homo sapiens)

as an input of

CAV3:TRIM72:DYSF binds ANXAs (Homo sapiens)

Other forms of this molecule

ANXA1 [extracellular region]

Cross References

RefSeq

XP_011516911.1, NP_000691.1

OpenTargets

ENSG00000135046

HPA

ENSG00000135046-ANXA1

GeneCards

P04083

Ensembl

ENSG00000135046, ENSP00000257497, ENSP00000366109, ENST00000376911, ENST00000257497

PRO

P04083

Pharos - Targets

P04083

HMDB Protein

HMDBP07452

PDB

5VFW, 1QLS, 1BO9, 1AIN

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.772	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	10
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.558	3
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:Q6P5S2 LEG1H			0.556	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.556	6
UniProt:Q9NVM1 EVA1B			0.556	3
UniProt:Q9C0E8-2 LNPK			0.556	3
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.556	5
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668)	0.527	2
UniProt:P43631 KIR2DS2	1	KIR2DS2 [plasma membrane] (R-HSA-199534)	0.527	2
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.527	2
UniProt:Q8N878 FRMD1			0.527	2
UniProt:A0A0F6B5H5 A0A0F6B5H5			0.499	2
UniProt:A0A0F6AZQ1 A0A0F6AZQ1			0.499	2

Cite Us!