CAV3:TRIM72:DYSF binds ANXAs

Stable Identifier
R-HSA-5263628
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane, cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CAV3:TRIM72:DYSF binds ANXAs
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mechanical stress and repetitive muscle contraction often causes membrane disruption to the sarcolemma. Healthy muscle is able to repair these disruptions by a Ca2+-dependent pathway. The combination of dysferlin (DYSF), caveolin 3 (CAV3) and tripartite motif-containing protein 72 (TRIM72 aka MG53) appears to be essential for the repair of muscle membrane damage (Cai et al. 2009). DYSF subsequently binds annexin A6 (ANXA6), a member of a family of phospholipid-binding proteins in a Ca2+-dependent manner. This interaction has been demonstrated in imaging experiments in zebrafish (Roostalu U & Strahle 2012). This interaction creates a platform for interacting proteins at the sarcolemma membrane surface and sequential recruitment of annexin A1 and A2 (ANXA1 and 2) to the repair site. The human event is deduced on the basis of experiments performed in mice (Lennon et al. 2003).
Literature References
PubMed ID Title Journal Year
22421042 In vivo imaging of molecular interactions at damaged sarcolemma

Strähle, U, Roostalu, U

Dev. Cell 2012
14506282 Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing

Brown, RH, Hyman, BT, Bacskai, BJ, Perlmutter, SL, Kho, A, Lennon, NJ

J. Biol. Chem. 2003
19380584 Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin

Cai, C, Nishi, M, Ko, JK, Sunada, Y, Weisleder, N, Takeshima, H, Ma, J, Komazaki, S

J. Biol. Chem. 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
Ca2+ [cytosol]
Inferred From
Cav3:Trim72:Dysf binds Anxas (Mus musculus)
Authored
Jassal, B  (2014-02-12)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-02-12)
Cite Us!