CACFD1 dimer transports Ca2+ from extracellular region to cytosol

Stable Identifier
R-HSA-5263618
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In drosophila, the calcium channel flower (fwe) is a homomultimeric protein on the plasma membrane of cells that couples synaptic exocytosis with endocytosis, both processes being regulated by Ca2+. Influx of Ca2+, triggered by voltage-gated Ca2+ channels, is necessary for synaptic vesicle fusion with the plasma membrane. Drosophila fwe is able to mediate Ca2+ influx and thus regulate synaptic endocytosis. Fwe can form at least a dimer but also higher multimers (Yao et al. 2009). The function of human calcium channel flower homologue (CACFD1) is based on inference from functional drosophila fwe.

Literature References
PubMed ID Title Journal Year
19737521 A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis

Yao, CK, Lin, YQ, Ly, CV, Ohyama, T, Haueter, CM, Moiseenkova-Bell, VY, Wensel, TG, Bellen, HJ

Cell 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium channel activity of CACFD1 dimer [plasma membrane]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
Reviewed
Created