Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Metabolism of ingested MeSeO2H into MeSeH
Stable Identifier
R-HSA-5263617
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested MeSeO2H into MeSeH (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
Methylseleninic acid (MeSeO2H) is reduced to methylselenenic acid (MeSeOH) and then further reduced to methylselenol (MeSeH) by thioredoxin reductase (TXNRD1).
Literature References
PubMed ID
Title
Journal
Year
11782468
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium
Gross, JH
,
Gromer, S
J. Biol. Chem.
2002
19406206
Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase
Lu, J
,
Berndt, C
,
Holmgren, A
Biochim. Biophys. Acta
2009
Participants
Events
MeSeO2H is reduced to MeSeOH by TXNRD1
(Homo sapiens)
MeSeOH is reduced to MeSeH by TXNRD1
(Homo sapiens)
Participates
as an event of
Selenoamino acid metabolism (Homo sapiens)
Event Information
Go Biological Process
selenium compound metabolic process (0001887)
Orthologous Events
Metabolism of ingested MeSeO2H into MeSeH (Bos taurus)
Metabolism of ingested MeSeO2H into MeSeH (Caenorhabditis elegans)
Metabolism of ingested MeSeO2H into MeSeH (Gallus gallus)
Metabolism of ingested MeSeO2H into MeSeH (Mus musculus)
Metabolism of ingested MeSeO2H into MeSeH (Plasmodium falciparum)
Metabolism of ingested MeSeO2H into MeSeH (Rattus norvegicus)
Authored
Williams, MG (2014-05-06)
Reviewed
Rush, MG (2015-08-30)
Created
Williams, MG (2014-02-12)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text