Reactome | CACNA1S [plasma membrane]

CACNA1S [plasma membrane]

Stable Identifier

R-HSA-525807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Voltage-dependent L-type calcium channel subunit alpha-1S, CAC1S_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - NCAM signaling for neurite out-growth (Homo sapiens)
      - NCAM1 interactions (Homo sapiens)
        
        NCAM1 interacts with T- and L-type VDCC (Homo sapiens)
        
        NCAM1:T- and L-type VDCC [plasma membrane] (Homo sapiens)
        
        T- and L-type VDCC [plasma membrane] (Homo sapiens)
        
        L-type VDCC [plasma membrane] (Homo sapiens)
        
        CACNA1S [plasma membrane] (Homo sapiens)
        
        T- and L-type VDCC [plasma membrane] (Homo sapiens)
        
        L-type VDCC [plasma membrane] (Homo sapiens)
        
        CACNA1S [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13698 CACNA1S

Gene Names

CACNA1S, CACH1, CACN1, CACNL1A3

Chain

chain:1-1873

Reference Genes

BioGPS Gene:779 CACNA1S

COSMIC (genes):CACNA1S CACNA1S

CTD Gene:779 CACNA1S

dbSNP Gene:779 CACNA1S

ENSEMBL:ENSG00000081248 CACNA1S

ENSEMBL:ENSG00000081248.12 CACNA1S

HGNC:1397 CACNA1S

KEGG Gene (Homo sapiens):779 CACNA1S

Monarch:779 CACNA1S

NCBI Gene:779 CACNA1S

OMIM:114208 CACNA1S

UCSC:Q13698 CACNA1S

Reference Transcript

RefSeq:NM_000069.2 CACNA1S

Other Identifiers

11731808_at

16697794

217515_PM_s_at

217515_s_at

2450569

2450570

2450571

2450573

2450574

2450575

2450576

2450577

2450578

2450581

2450585

2450586

2450587

2450589

2450592

2450594

2450596

2450598

2450600

2450601

2450602

2450603

2450605

2450608

2450609

2450610

2450611

2450613

2450614

2450615

2450616

2450617

2450618

2450622

2450624

2450625

2450626

2450627

2450631

2450632

2450633

2450636

2450637

2450638

2450639

2450640

2450641

2450646

2450649

2450650

34913_at

779

7923271

A_23_P85765

GE80885

GO:0001501

GO:0002074

GO:0003012

GO:0005215

GO:0005216

GO:0005244

GO:0005245

GO:0005262

GO:0005515

GO:0005516

GO:0005737

GO:0005783

GO:0005886

GO:0005891

GO:0006811

GO:0006816

GO:0006936

GO:0006941

GO:0007029

GO:0007519

GO:0007520

GO:0007528

GO:0008331

GO:0016020

GO:0016529

GO:0030154

GO:0030315

GO:0031674

GO:0034330

GO:0034765

GO:0036094

GO:0043226

GO:0043501

GO:0045933

GO:0046872

GO:0048741

GO:0048856

GO:0055001

GO:0055085

GO:0070588

GO:0071313

GO:0098703

GO:0098772

GO:0140677

GO:1990454

HMNXSV003013997

Hs.328199.0.A1_3p_s_at

ILMN_1667980

L33798_at

PH_hs_0000174

TC01003684.hg

TC01006032.hg

TC01006033.hg

Participates

as a member of

L-type VDCC [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_000060.2

ZINC - World Drugs

CAC1S_HUMAN

Guide to Pharmacology - Targets

528

OpenTargets

ENSG00000081248

ZINC - FDA approved

CAC1S_HUMAN

ZINC - Substances

CAC1S_HUMAN

ZINC target

Q13698

ZINC - Biogenic

CAC1S_HUMAN

PRO

Q13698

PDB

2VAY, 6B27

ZINC - Investigational

CAC1S_HUMAN

HPA

ENSG00000081248-CACNA1S

GeneCards

Q13698

Ensembl

ENSP00000355192, ENSG00000081248, ENST00000362061

Pharos - Targets

Q13698

Orphanet

15394

ZINC - Predictions - Purchasable

CAC1S_HUMAN

HMDB Protein

HMDBP07498

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86UT5 NHERF4	1	PDZD3 [plasma membrane] (R-HSA-8936367)	0.556	3