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HSPA6 [nucleoplasm]
Stable Identifier
R-HSA-5252088
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Heat shock 70 kDa protein 6
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)
HSP70s:ADP [nucleoplasm] (Homo sapiens)
HSPA6:ADP [nucleoplasm] (Homo sapiens)
HSPA6 [nucleoplasm] (Homo sapiens)
Hikeshi:HSP70s:ATP [nucleoplasm] (Homo sapiens)
HSP70s:ATP [nucleoplasm] (Homo sapiens)
HSPA6:ATP [nucleoplasm] (Homo sapiens)
HSPA6 [nucleoplasm] (Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
Hikeshi:HSP70s:ATP [nucleoplasm] (Homo sapiens)
HSP70s:ATP [nucleoplasm] (Homo sapiens)
HSPA6:ATP [nucleoplasm] (Homo sapiens)
HSPA6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17066 HSPA6
Gene Names
HSPA6, HSP70B'
Chain
chain:1-643
Reference Genes
BioGPS Gene:3310 HSPA6
COSMIC (genes):HSPA6 HSPA6
CTD Gene:3310 HSPA6
dbSNP Gene:3310 HSPA6
ENSEMBL:ENSG00000173110 HSPA6
HGNC:5239 HSPA6
KEGG:hsa:3310 HSPA6
Monarch:3310 HSPA6
NCBI Gene:3310 HSPA6
OMIM:140555 HSPA6
UCSC:P17066 HSPA6
Reference Transcript
RefSeq:NM_002155.4 HSPA6
Other Identifiers
11723050_a_at
11757367_s_at
117_3p_at
117_PM_at
117_at
16672914
213418_PM_at
213418_at
2363785
2363786
2363787
2363788
2363789
2363790
2363791
2363792
2363793
2363794
2363795
2363796
2363797
3310
35965_at
56711_s_at
7906764
7906775
A_14_P107820
A_23_P114903
GE59761
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005814
GO:0005829
GO:0005886
GO:0006457
GO:0006986
GO:0008180
GO:0016787
GO:0016887
GO:0019899
GO:0031072
GO:0031625
GO:0031982
GO:0034605
GO:0034774
GO:0042026
GO:0043226
GO:0044183
GO:0051082
GO:0051085
GO:0070062
GO:0072562
GO:0140657
GO:0140662
GO:1904813
Hs.3268.0.S1_3p_at
ILMN_1658383
ILMN_1806165
PH_hs_0000400
TC01001401.hg
TC01004796.hg
X51757_at
X51757cds_3p_at
X51757cds_3p_s_at
Participates
as a component of
HSPA6:ADP [nucleoplasm] (Homo sapiens)
HSPA6:ATP [nucleoplasm] (Homo sapiens)
Other forms of this molecule
HSPA6 [cytosol]
HSPA6 [ficolin-1-rich granule lumen]
HSPA6 [extracellular region]
HSPA6 [secretory granule lumen]
Inferred To
hspE-2 [nucleoplasm]
(Dictyostelium discoideum)
hsp70.3 [nucleoplasm]
(Danio rerio)
ssa2 [nucleoplasm]
(Schizosaccharomyces pombe)
SSA4 [nucleoplasm]
(Saccharomyces cerevisiae)
hsp70.1 [nucleoplasm]
(Danio rerio)
Homologues of HSPA6 [nucleoplasm]
(Danio rerio)
Homologues of HSPA6 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of HSPA6 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of HSPA6 [nucleoplasm]
(Schizosaccharomyces pombe)
SSA3 [nucleoplasm]
(Saccharomyces cerevisiae)
ssa1 [nucleoplasm]
(Schizosaccharomyces pombe)
Ghost homologue of HSPA6 [nucleoplasm]
(Xenopus tropicalis)
HSPA6 [nucleoplasm]
(Bos taurus)
HSPA6 [nucleoplasm]
(Caenorhabditis elegans)
HSPA6 [nucleoplasm]
(Dictyostelium discoideum)
HSPA6 [nucleoplasm]
(Saccharomyces cerevisiae)
HSPA6 [nucleoplasm]
(Schizosaccharomyces pombe)
HSPA6 [nucleoplasm]
(Sus scrofa)
hspB [nucleoplasm]
(Dictyostelium discoideum)
hsp70l [nucleoplasm]
(Danio rerio)
SSA2 [nucleoplasm]
(Saccharomyces cerevisiae)
SSA1 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
Guide to Pharmacology - Targets
2542
ENSEMBL
ENST00000309758
,
ENSP00000310219
OpenTargets
ENSG00000173110
HPA
ENSG00000173110-HSPA6
PRO
P17066
Pharos - Targets
P17066
GlyGen
P17066
PDB
3FE1
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99558 MAP3K14
5
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.564
3
UniProt:O95429 BAG4
3
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.556
3
UniProt:P27694 RPA1
2
RPA1 [nucleoplasm]
(R-HSA-68461)
polySUMO2,3-K449,K577-RPA1 [nucleoplasm]
(R-HSA-4551644)
0.556
3
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.527
3
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