AZGP1 binds PIP

Stable Identifier
R-HSA-5252072
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Zinc-alpha-2-glycoprotein (AZGP1) (Sanchez et al. 1997), a 41 kDa protein secreted in many bodily fluids, is thought to stimulate lipolysis and be the cause of the excessive fat loss seen in cancer cachexia (Russell et al. 2004). AZGP1 is able to bind prolactin-inducible protein (PIP) (Myal et al. 1991), another secreted protein overexpressed in certain breast cancers (Hassan et al. 2008, Debily et al. 2009).

Literature References
PubMed ID Title Journal Year
19262752 A functional and regulatory network associated with PIP expression in human breast cancer

Debily, MA, Marhomy, SE, Boulanger, V, Eveno, E, Mariage-Samson, R, Camarca, A, Auffray, C, Piatier-Tonneau, D, Imbeaud, S

PLoS ONE 2009
9114041 Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog

Sánchez, LM, López-Otin, C, Bjorkman, PJ

Proc. Natl. Acad. Sci. U.S.A. 1997
1955075 The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation

Myal, Y, Robinson, DB, Iwasiow, B, Tsuyuki, D, Wong, P, Shiu, RP

Mol. Cell. Endocrinol. 1991
18930737 Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma

Hassan, MI, Bilgrami, S, Kumar, V, Singh, N, Yadav, S, Kaur, P, Singh, TP

J. Mol. Biol. 2008
14984739 Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein

Russell, ST, Zimmerman, TP, Domin, BA, Tisdale, MJ

Biochim. Biophys. Acta 2004
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