Reactome | AZGP1 binds PIP

AZGP1 binds PIP

Stable Identifier

R-HSA-5252072

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Zinc-alpha-2-glycoprotein (AZGP1) (Sanchez et al. 1997), a 41 kDa protein secreted in many bodily fluids, is thought to stimulate lipolysis and be the cause of the excessive fat loss seen in cancer cachexia (Russell et al. 2004). AZGP1 is able to bind prolactin-inducible protein (PIP) (Myal et al. 1991), another secreted protein overexpressed in certain breast cancers (Hassan et al. 2008, Debily et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
9114041	Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog Sánchez, LM, López-Otin, C, Bjorkman, PJ	Proc. Natl. Acad. Sci. U.S.A.	1997
19262752	A functional and regulatory network associated with PIP expression in human breast cancer Debily, MA, Marhomy, SE, Boulanger, V, Eveno, E, Mariage-Samson, R, Camarca, A, Auffray, C, Piatier-Tonneau, D, Imbeaud, S	PLoS ONE	2009
1955075	The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation Myal, Y, Robinson, DB, Iwasiow, B, Tsuyuki, D, Wong, P, Shiu, RP	Mol. Cell. Endocrinol.	1991
18930737	Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma Hassan, MI, Bilgrami, S, Kumar, V, Singh, N, Yadav, S, Kaur, P, Singh, TP	J. Mol. Biol.	2008
14984739	Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein Russell, ST, Zimmerman, TP, Domin, BA, Tisdale, MJ	Biochim. Biophys. Acta	2004