BoNT/G LC cleaves target cell VAMP1

Stable Identifier
R-HSA-5250978
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
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Botulinum toxin type G light chain (BoNT/G LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 1 (VAMP1). BoNT/G LC is a zinc metalloprotease (Schiavo et al. 1994; Yamasaki et al. 1994). VAMP1 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis.Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).

Literature References
PubMed ID Title Journal Year
7910017 Botulinum neurotoxin type G proteolyses the Ala81-Ala82 bond of rat synaptobrevin 2

Yamasaki, S, Binz, T, Hayashi, T, Szabo, E, Yamasaki, N, Eklund, M, Jahn, R, Niemann, H

Biochem. Biophys. Res. Commun. 1994
7527117 Mechanism of action of tetanus and botulinum neurotoxins

Montecucco, C, Schiavo, G

Mol Microbiol 1994
8051110 Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond

Schiavo, G, Malizio, C, Trimble, WS, Polverino de Laureto, P, Milan, G, Sugiyama, H, Johnson, EA, Montecucco, C

J. Biol. Chem. 1994
15217342 The synaptic vesicle cycle

S├╝dhof, TC

Annu Rev Neurosci 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of BoNT/G LC:Zn2+ [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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Reviewed
Created