botF HC:LC binds SV2A or B or C and GT1b on the target cell surface

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Clostridium botulinum
Locations in the PathwayBrowser
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The botulinum toxin type F disulfide-bonded heavy chain - light chain heterodimer ("dichain") (botF HC:LC, encoded by the C. botulinum botF gene) binds ganglioside GT1b and synaptic vesicle protein 2A (SV2A), B (SV2B), or C (SV2C) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SV2A, B, or C when those proteins are exposed at the cell surface by exocytosis (Fu et al. 2009; Rummel et al. 2009).
Literature References
PubMed ID Title Journal Year
19650874 Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

Mahrhold, S, Darashchonak, N, Häfner, K, Rummel, A, Holt, M, Binz, T, Bigalke, H, Jahn, R, Beermann, S, Karnath, T

J. Neurochem. 2009
19476346 Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F

Baldwin, MR, Barbieri, JT, Chen, C, Kim, JJ, Fu, Z

Biochemistry 2009
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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