Reactome | ARL2:GTP binds ARL2BP

ARL2:GTP binds ARL2BP

Stable Identifier

R-HSA-5250217

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ADP-ribosylation factor-like protein 2 (ARL2) is a small (21kDa) GTPase protein that is able to bind GDP or GTP. It is implicated in a range of processes from trafficking processes to regulation of microtuble dynamics. ADP-ribosylation factor-like protein 2-binding protein (ARL2BP aka BART) is an effector protein that binds ARL2 (Zhang et al. 2009, Bailey et al. 2009). This binding is dependent on ARL2 being in its GTP-bound form.

Literature References

PubMed ID	Title	Journal	Year
19368893	Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector Zhang, T, Li, S, Zhang, Y, Zhong, C, Lai, Z, Ding, J	Structure	2009
18981177	The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function Bailey, LK, Campbell, LJ, Evetts, KA, Littlefield, K, Rajendra, E, Nietlispach, D, Owen, D, Mott, HR	J. Biol. Chem.	2009