ARL2:GTP binds ARL2BP

Stable Identifier
R-HSA-5250217
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ADP-ribosylation factor-like protein 2 (ARL2) is a small (21kDa) GTPase protein that is able to bind GDP or GTP. It is implicated in a range of processes from trafficking processes to regulation of microtuble dynamics. ADP-ribosylation factor-like protein 2-binding protein (ARL2BP aka BART) is an effector protein that binds ARL2 (Zhang et al. 2009, Bailey et al. 2009). This binding is dependent on ARL2 being in its GTP-bound form.

Literature References
PubMed ID Title Journal Year
18981177 The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function

Bailey, LK, Campbell, LJ, Evetts, KA, Littlefield, K, Rajendra, E, Nietlispach, D, Owen, D, Mott, HR

J. Biol. Chem. 2009
19368893 Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector

Zhang, T, Li, S, Zhang, Y, Zhong, C, Lai, Z, Ding, J

Structure 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!