Reactome | ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix

ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix

Stable Identifier

R-HSA-5250210

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, cytosol

ReviewStatus

5/5

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ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix

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When ADP-ribosylation factor-like protein 2-binding protein (ARL2BP aka BART) binds GTP-bound ADP-ribosylation factor-like protein 2 (ARL2:GTP), the resultant complex can enter the mitochondrion via an unknown mechanism (Zhang et al. 2009, Bailey et al. 2009). Although ARL2 is a member of the ARF family of G proteins, it lacks the myristoylation at glycine-2 characteristic of that family and thus can move across the mitochondrial membrane into the intermembrane space (Sharer et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
19368893	Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector Ding, J, Li, S, Zhang, T, Lai, Z, Zhang, Y, Zhong, C	Structure	2009
11809823	ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter Sharer, JD, Wallace, DC, Kahn, RA, Van Valkenburgh, H, Shern, JF	Mol. Biol. Cell	2002
18981177	The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function Mott, HR, Campbell, LJ, Owen, D, Rajendra, E, Bailey, LK, Nietlispach, D, Evetts, KA, Littlefield, K	J. Biol. Chem.	2009