ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix

Stable Identifier
Reaction [transition]
Homo sapiens
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When ADP-ribosylation factor-like protein 2-binding protein (ARL2BP aka BART) binds GTP-bound ADP-ribosylation factor-like protein 2 (ARL2:GTP), the resultant complex can enter the mitochondrion via an unknown mechanism (Zhang et al. 2009, Bailey et al. 2009). Although ARL2 is a member of the ARF family of G proteins, it lacks the myristoylation at glycine-2 characteristic of that family and thus can move across the mitochondrial membrane into the intermembrane space (Sharer et al. 2002).
Literature References
PubMed ID Title Journal Year
19368893 Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector

Ding, J, Li, S, Zhang, T, Lai, Z, Zhang, Y, Zhong, C

Structure 2009
11809823 ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter

Sharer, JD, Wallace, DC, Kahn, RA, Van Valkenburgh, H, Shern, JF

Mol. Biol. Cell 2002
18981177 The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function

Mott, HR, Campbell, LJ, Owen, D, Rajendra, E, Bailey, LK, Nietlispach, D, Evetts, KA, Littlefield, K

J. Biol. Chem. 2009
Orthologous Events
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