botC HC:LC binds GT1b on the target cell surface

Stable Identifier
R-HSA-5246506
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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botC HC:LC binds GT1b on the target cell surface
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The botulinum toxin type C disulfide-bonded heavy chain - light chain heterodimer (“dichain”) (botC HC:LC, encoded by the C. botulinum botC1 gene) binds two molecules of GT1b ganglioside on the plasma membrane of a human target cell (Karalewitz et al. 2012).

Literature References
PubMed ID Title Journal Year
23027864 Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry

Baldwin, MR, Barbieri, JT, Kim, JJ, Fu, Z, Karalewitz, AP

J. Biol. Chem. 2012
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Gopinathrao, G  (2006-06-15)
Krupa, S  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-22)
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