BoNT/C HC:LC binds GT1b on the target cell surface

Stable Identifier
R-HSA-5246506
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
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The botulinum toxin type C disulfide-bonded heavy chain - light chain heterodimer (“dichain”) (BoNT/C HC:LC, encoded by the C. botulinum botC1 gene) binds two molecules of GT1b ganglioside on the plasma membrane of a human target cell (Karalewitz et al. 2012).

Literature References
PubMed ID Title Journal Year
23027864 Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry

Karalewitz, AP, Fu, Z, Baldwin, MR, Kim, JJ, Barbieri, JT

J. Biol. Chem. 2012
Participants
Participant Of
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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