Reactome | APOM binds retinoids

APOM binds retinoids

Stable Identifier

R-HSA-5246478

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Apoliprotein M (APOM) is a plasma protein usually associated with HDLs and to a lesser extent, with LDLs. APOM could be classed as a lipocalin (LCN) because it shares the structurally conserved beta-barrel, which in many LCNs, binds hydrophobic ligands. Mature APOM retains its signal peptide, which serves as a lipid anchor to attach it to lipoproteins, thereby keeping it in the circulation (Christoffersen et al. 2008). APOM is able to bind retinoids such as retinol, all-trans-retinoate and 9-cis-retinoate with low affinity although they may not be the natural ligands (Ahnstrom et al. 2007, Dahlback & Nielsen 2009). APOM does not bind cholesterol, vitamin K or arachidonate (Ahnstrom et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17525477	Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M Faber, K, Ahnström, J, Dahlbäck, B, Axler, O	J. Lipid Res.	2007
18460466	The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma Ahnström, J, Nielsen, LB, Christensen, EI, Dahlbäck, B, Christoffersen, C, Axler, O	J. Biol. Chem.	2008