APOM binds retinoids

Stable Identifier
R-HSA-5246478
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Apoliprotein M (APOM) is a plasma protein usually associated with HDLs and to a lesser extent, with LDLs. APOM could be classed as a lipocalin (LCN) because it shares the structurally conserved beta-barrel, which in many LCNs, binds hydrophobic ligands. Mature APOM retains its signal peptide, which serves as a lipid anchor to attach it to lipoproteins, thereby keeping it in the circulation (Christoffersen et al. 2008). APOM is able to bind retinoids such as retinol, all-trans-retinoate and 9-cis-retinoate with low affinity although they may not be the natural ligands (Ahnstrom et al. 2007, Dahlback & Nielsen 2009). APOM does not bind cholesterol, vitamin K or arachidonate (Ahnstrom et al. 2007).

Literature References
PubMed ID Title Journal Year
18460466 The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma

Christoffersen, C, Ahnström, J, Axler, O, Christensen, EI, Dahlbäck, B, Nielsen, LB

J. Biol. Chem. 2008
17525477 Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M

Ahnström, J, Faber, K, Axler, O, Dahlbäck, B

J. Lipid Res. 2007
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