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SV2C [synaptic vesicle membrane]
Stable Identifier
R-HSA-5244432
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
synaptic vesicle membrane
Synonyms
Synaptic vesicle glycoprotein 2C, SV2C_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Neurotoxicity of clostridium toxins (Homo sapiens)
Toxicity of botulinum toxin type A (botA) (Homo sapiens)
botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
botA HC:LC dimer:SV2:GT1b [synaptic vesicle membrane] (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
Toxicity of botulinum toxin type D (botD) (Homo sapiens)
botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
botD:SV2:GD2 [synaptic vesicle membrane] (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
botD:SV2:GD2 [synaptic vesicle membrane] (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
Toxicity of botulinum toxin type F (botF) (Homo sapiens)
botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
botF:SV2:GT1b [synaptic vesicle membrane] (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)
botF:SV2:GT1b [synaptic vesicle membrane] (Homo sapiens)
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
SV2C [synaptic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q496J9 SV2C
Gene Names
SV2C, KIAA1054
Chain
chain:1-727
Reference Genes
BioGPS Gene:22987 SV2C
COSMIC (genes):SV2C SV2C
CTD Gene:22987 SV2C
dbSNP Gene:22987 SV2C
ENSEMBL:ENSG00000122012.14 SV2C
HGNC:30670 SV2C
KEGG Gene (Homo sapiens):22987 SV2C
Monarch:22987 SV2C
NCBI Gene:22987 SV2C
OMIM:610291 SV2C
UCSC:Q496J9 SV2C
Reference Transcript
RefSeq:XM_011543282.2 SV2C
RefSeq:NM_014979.3 SV2C
RefSeq:XM_011543281.2 SV2C
Other Identifiers
0004120373
11733590_a_at
16986333
216086_PM_at
216086_at
22987
242530_PM_at
242530_at
243139_PM_at
243139_at
2816227
2816228
2816229
2816233
2816235
2816237
2816244
2816246
2816250
2816252
2816254
2816256
2816258
2816262
2816264
2816266
2816268
2816270
2816272
2816274
2816275
2816277
2816279
34132_at
59550_at
61003_at
8106336
A_14_P118683
A_23_P417646
A_32_P199573
A_33_P3314301
GE537332
GE611825
GO:0005215
GO:0005515
GO:0005622
GO:0005737
GO:0005886
GO:0006836
GO:0007268
GO:0008021
GO:0016020
GO:0016021
GO:0022857
GO:0023052
GO:0030285
GO:0030672
GO:0031410
GO:0043005
GO:0043226
GO:0045202
GO:0055085
HMNXSV003029018
HMNXSV003036518
Hs.225974.0.S1_3p_at
Hs.268806.0.A1_3p_at
Hs.94002.0.A1_3p_at
ILMN_1724352
ILMN_1900968
PH_hs_0012619
TC05000366.hg
TC05002457.hg
p13721
Participates
as a member of
SV2A,B,C [synaptic vesicle membrane] (Homo sapiens)
Other forms of this molecule
SV2C [plasma membrane]
Cross References
RefSeq
XP_011541583.1
,
NP_055794.3
,
XP_011541584.2
OpenTargets
ENSG00000122012
HPA
ENSG00000122012-SV2C
GeneCards
Q496J9
Ensembl
ENST00000502798
,
ENSP00000423541
,
ENSG00000122012
PRO
Q496J9
Pharos - Targets
Q496J9
HMDB Protein
HMDBP08022
PDB
6ES1
,
4JRA
,
5MOY
,
5JLV
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DPI0 botA
8
botA HC disulfide bonded [plasma membrane]
(R-CBO-9616788)
botA LC disulfide bonded [plasma membrane]
(R-CBO-9616803)
botA HC [synaptic vesicle membrane]
(R-CBO-9616778)
botA LC disulfide bonded [synaptic vesicle membrane]
(R-CBO-9616804)
botA HC disulfide bonded [synaptic vesicle membrane]
(R-CBO-9616795)
botA LC [cytosol]
(R-CBO-9616805)
botA HC disulfide bonded [extracellular region]
(R-CBO-9616783)
botA LC disulfide bonded [extracellular region]
(R-CBO-9616802)
0.618
4
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