BoNT/A:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane

Stable Identifier
R-HSA-5244424
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
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Synaptic vesicles re form rapidly after exocytosis, carrying vesicle membrane proteins that had been exposed on the cell surface by exocytosis back into the cell (Sudhoff 2004). The botulinum toxin type A disulfide bonded heavy chain - light chain heterodimer (“dichain”) (BoNT/A HC:LC) bound to ganglioside GT1b and synaptic vesicle protein 2A, 2B, or 2C (SV2A, B, or C) is inferred to be taken up as well, delivering it to the re-formed synaptic vesicle.

Literature References
PubMed ID Title Journal Year
15217342 The synaptic vesicle cycle

Südhof, TC

Annu Rev Neurosci 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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