Reactome | PDE4D [cytosol]

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PDE4D

Stable Identifier

R-HSA-52389

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-specific 3',5'-cyclic phosphodiesterase 4D , DPDE3, PDE43

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        cAMP hydrolysis by PDE 4 (Homo sapiens)
        
        PDE 4 [cytosol] (Homo sapiens)
        
        PDE4D [cytosol] (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
        
        PDE 4 [cytosol] (Homo sapiens)
        
        PDE4D [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q08499 PDE4D

Gene Names

PDE4D, DPDE3

Chain

chain:1-809

Reference Genes

BioGPS Gene:5144 PDE4D

COSMIC (genes):PDE4D PDE4D

CTD Gene:5144 PDE4D

dbSNP Gene:5144 PDE4D

ENSEMBL:ENSG00000113448 PDE4D

HGNC:8783 PDE4D

KEGG Gene (Homo sapiens):hsa:5144 PDE4D

Monarch:5144 PDE4D

NCBI Gene:5144 PDE4D

OMIM:600129 PDE4D

UCSC:Q08499 PDE4D

Reference Transcript

Other Identifiers

0001850022

11724446_a_at

11724447_a_at

11740511_a_at

11740512_x_at

11740513_a_at

11746907_a_at

11760661_at

1554717_a_at

1E9K

1MKD

1OYN

1PTW

1Q9M

1TB7

1TBB

1XOM

1XON

1XOQ

1XOR

1Y2B

1Y2C

1Y2D

1Y2E

1Y2K

1ZKN

204491_at

210836_x_at

210837_s_at

211840_s_at

228962_at

2858135

2858136

2858137

2858138

2858139

2858140

2858141

2858142

2858143

2858144

2858145

2858148

2858149

2858150

2858151

2858152

2858154

2858155

2858156

2858166

2858168

2858169

2858174

2858195

2858196

2858209

2858211

2858215

2858221

2858222

2858240

2858241

2858257

2858258

2858290

2858291

2858292

2858345

2858346

2858347

2858368

2858369

2858370

2858384

2858406

2858407

2858408

2858433

2FM0

2FM5

2PW3

2QYN

38526_at

3G4G

3G4I

3G4K

3G4L

3G58

3IAD

3IAK

3K4S

3SL3

3SL4

3SL5

3SL6

3SL8

3V9B

45895

4OGB

4W1O

4WCU

5144

5K1I

5K32

5TKB

5WQA

61634_r_at

77831_at

90755_at

A0A140VJR0

A_23_P124456

A_23_P158406

A_24_P419351

A_24_P944519

A_33_P3389649

A_33_P3389653

A_33_P3389658

CCDS47213

CCDS54858

CCDS54859

CCDS56369

CCDS56370

CCDS56371

CCDS56372

CCDS56373

ENSG00000113448

ENSP00000308485

ENSP00000321739

ENSP00000345502

ENSP00000351800

ENSP00000353152

ENSP00000384806

ENSP00000423094

ENSP00000424852

ENSP00000425605

ENSP00000425917

ENST00000309641

ENST00000317118

ENST00000340635

ENST00000358923

ENST00000360047

ENST00000405755

ENST00000502484

ENST00000502575

ENST00000503258

ENST00000507116

EntrezGene:5144

g1236954_3p_a_at

g2735858_3p_a_at

GE81610

GO:0002027

GO:0004114

GO:0004115

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005891

GO:0006198

GO:0006939

GO:0007165

GO:0007186

GO:0007568

GO:0008081

GO:0008144

GO:0010469

GO:0010880

GO:0016020

GO:0016324

GO:0016787

GO:0019899

GO:0019933

GO:0030552

GO:0030593

GO:0030814

GO:0031698

GO:0031965

GO:0032729

GO:0032743

GO:0032754

GO:0033137

GO:0034704

GO:0035264

GO:0044325

GO:0045822

GO:0046872

GO:0050852

GO:0050900

GO:0051117

GO:0060314

GO:0061028

GO:0071222

GO:0071872

GO:0071875

GO:0086004

GO:0086024

GO:0097110

GO:1901844

GO:1901898

HGNC:8783

HPA045895

Hs.117545

Hs.172081.0.S3_3p_at

Hs.28482.0.A1_3p_at

Hs.669817

Hs.706461

Hs2.172081.3.S1_3p_s_at

ILMN_1791483

NM_001104631

NM_001165899

NM_001197218

NM_001197219

NM_001197220

NM_001197221

NM_001197222

NM_001197223

NM_001349241

NM_001349242

NM_006203

NP_001098101

NP_001159371

NP_001184147

NP_001184148

NP_001184149

NP_001184150

NP_001184151

NP_001184152

NP_001336170

NP_001336171

NP_006194

PDE4D

PDE4D-201

PDE4D-202

PDE4D-203

PDE4D-204

PDE4D-205

PDE4D-207

PDE4D-208

PDE4D-209

PDE4D-210

PDE4D-216

PF00233

PH_hs_0022076

PR00387

uc003jrs.4

uc003jrt.4

uc003jrv.4

uc003jrw.4

uc003jrx.4

uc003jrz.5

uc003jsa.4

uc003jsb.5

uc003jsc.4

uc063dvf.1

UPI000002A6DF

UPI000003622A

UPI0000050EB1

UPI0000050EB3

UPI0000050EB4

UPI0000050EB5

UPI0000050EB7

UPI0000070BB2

UPI0000074652

UPI00001ADDE3

XM_005248538

XM_011543469

XM_011543470

XM_011543471

XM_011543473

XM_011543477

XM_017009565

XM_017009566

XM_017009567

XM_017009568

XM_017009570

XM_017009571

XP_005248595

XP_011541771

XP_011541772

XP_011541773

XP_011541775

XP_011541779

XP_016865054

XP_016865055

XP_016865056

XP_016865059

Participant Of

hasMember

PDE 4 [cytosol]

Inferred To

Homologues of PDE4D [cytosol] (Danio rerio)

Homologues of PDE4D [cytosol] (Drosophila melanogaster)

PDE4D [cytosol] (Bos taurus)

PDE4D [cytosol] (Caenorhabditis elegans)

PDE4D [cytosol] (Canis familiaris)

PDE4D [cytosol] (Danio rerio)

PDE4D [cytosol] (Drosophila melanogaster)

PDE4D [cytosol] (Gallus gallus)

PDE4D [cytosol] (Mus musculus)

PDE4D [cytosol] (Rattus norvegicus)

PDE4D [cytosol] (Sus scrofa)

PDE4D [cytosol] (Taeniopygia guttata)

PDE4D [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001184150.1, XP_005248595.1, NP_006194.2, NP_001184148.1, NP_001184149.1, NP_001184151.1, NP_001159371.1, NP_001098101.1, NP_001184152.1, XP_011541775.1, NP_001184147.1, XP_011541773.1, XP_016865055.1

Brenda

3.1.4.53

ZINC - World Drugs

PDE4D_HUMAN

ZINC - FDA approved

PDE4D_HUMAN

ZINC - Substances

PDE4D_HUMAN

ZINC - Biogenic

PDE4D_HUMAN

ZINC target

Q08499

PRO

Q08499

PDB

1XOQ, 1Y2B, 1ZKN, 2FM5, 3SL5, 3G4G, 2PW3, 1XOR, 3IAD, 1OYN, 1Y2E, 5K1I, 1TB7, 1XOM, 1Y2K, 1E9K, 3SL4, 3G58, 1XON, 2FM0, 5WQA, 3G4L, 1Y2C, 5K32, 1Q9M, 1Y2D, 3G4K, 3SL3, 1PTW, 4OGB, 2QYN, 5TKB, 1MKD, 3IAK, 4WCU, 1TBB, 3K4S, 3G4I, 3SL6, 3V9B, 4W1O, 3SL8

ZINC - Metabolites

PDE4D_HUMAN

GeneCards

Q08499

DOCK Blaster

3SL4, 1XOR, 1XOQ, 3V9B, 1Y2K, 1TB7, 1ZKN, 1Y2C, 1Y2B, 1Y2E, 1Y2D, 4W1O, 3G4I, 2PW3, 3K4S, 3G4L, 3G4K, 3G4G, 2FM0, 5WQA, 1Q9M, 3G58, 5TKB, 4WCU, 4OGB, 1TBB, 1OYN, 2FM5, 2QYN, 1MKD, 3IAK, 5K1I, 3SL8, 3IAD, 5K32, 3SL6, 3SL3, 3SL5, 1PTW, 1XOM, 1XON

Orphanet

21092

ZINC - Predictions - Purchasable

PDE4D_HUMAN

HMDB Protein

HMDBP00636

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.564	2
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3