Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PDE4D [cytosol]
Stable Identifier
R-HSA-52389
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cAMP-specific 3',5'-cyclic phosphodiesterase 4D , DPDE3, PDE43
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
PDE4A,C,D hydrolyse cAMP (Homo sapiens)
PDE4A,C,D [cytosol] (Homo sapiens)
PDE4D [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP phosphodiesterases [cytosol] (Homo sapiens)
Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
PDE4A,C,D [cytosol] (Homo sapiens)
PDE4D [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08499 PDE4D
Gene Names
PDE4D, DPDE3
Chain
chain:1-809
Reference Genes
BioGPS Gene:5144 PDE4D
COSMIC (genes):PDE4D PDE4D
CTD Gene:5144 PDE4D
dbSNP Gene:5144 PDE4D
ENSEMBL:ENSG00000113448 PDE4D
HGNC:8783 PDE4D
KEGG Gene (Homo sapiens):5144 PDE4D
Monarch:5144 PDE4D
NCBI Gene:5144 PDE4D
OMIM:600129 PDE4D
UCSC:Q08499 PDE4D
Reference Transcript
RefSeq:NM_006203.4 PDE4D
RefSeq:NM_001197219.1 PDE4D
RefSeq:XM_017009566.1 PDE4D
RefSeq:NM_001197220.1 PDE4D
RefSeq:NM_001197218.1 PDE4D
RefSeq:NM_001197223.1 PDE4D
RefSeq:XM_011543473.1 PDE4D
RefSeq:XM_011543471.1 PDE4D
RefSeq:NM_001197221.1 PDE4D
RefSeq:NM_001165899.1 PDE4D
RefSeq:NM_001197222.1 PDE4D
RefSeq:NM_001104631.1 PDE4D
RefSeq:XM_005248538.4 PDE4D
Other Identifiers
0001850022
11724446_a_at
11724447_a_at
11740511_a_at
11740512_x_at
11740513_a_at
11746907_a_at
11760661_at
1554717_a_at
204491_at
210836_x_at
210837_s_at
211840_s_at
228962_at
2858133
2858135
2858136
2858137
2858138
2858139
2858140
2858141
2858142
2858143
2858144
2858145
2858148
2858149
2858150
2858151
2858152
2858154
2858155
2858156
2858166
2858168
2858169
2858174
2858195
2858196
2858209
2858211
2858215
2858221
2858222
2858240
2858241
2858257
2858258
2858290
2858291
2858292
2858345
2858346
2858347
2858368
2858369
2858370
2858384
2858406
2858407
2858408
2858433
38526_at
5144
61634_r_at
77831_at
90755_at
A_23_P124456
A_23_P158406
A_24_P419351
A_24_P944519
A_33_P3389649
A_33_P3389653
A_33_P3389658
GE81610
GO:0002027
GO:0002376
GO:0003013
GO:0003674
GO:0004114
GO:0004115
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005891
GO:0006198
GO:0006464
GO:0006810
GO:0006939
GO:0007165
GO:0007186
GO:0007568
GO:0008081
GO:0008144
GO:0008150
GO:0009056
GO:0009058
GO:0010469
GO:0010880
GO:0016020
GO:0016324
GO:0016787
GO:0019899
GO:0019933
GO:0030154
GO:0030552
GO:0030593
GO:0031698
GO:0032729
GO:0032743
GO:0032754
GO:0032991
GO:0033137
GO:0034641
GO:0034655
GO:0034704
GO:0035264
GO:0040007
GO:0040011
GO:0042592
GO:0043167
GO:0043226
GO:0043951
GO:0044281
GO:0044325
GO:0045822
GO:0046872
GO:0048856
GO:0048870
GO:0050852
GO:0050900
GO:0051117
GO:0055085
GO:0060314
GO:0061028
GO:0071222
GO:0071872
GO:0071875
GO:0086004
GO:0086024
GO:0097110
GO:1901844
GO:1901898
Hs.172081.0.S3_3p_at
Hs.28482.0.A1_3p_at
Hs2.172081.3.S1_3p_s_at
ILMN_1791483
PH_hs_0022076
g1236954_3p_a_at
g2735858_3p_a_at
Participant Of
hasMember
PDE4A,C,D [cytosol]
Inferred To
pde4d [cytosol] (Danio rerio)
dnc [cytosol] (Drosophila melanogaster)
Homologues of PDE4D [cytosol] (Danio rerio)
Homologues of PDE4D [cytosol] (Dictyostelium discoideum)
Homologues of PDE4D [cytosol] (Plasmodium falciparum)
pde3 [cytosol] (Dictyostelium discoideum)
slain2 [cytosol] (Xenopus tropicalis)
PDE4D [cytosol] (Bos taurus)
PDE4D [cytosol] (Canis familiaris)
PDE4D [cytosol] (Gallus gallus)
PDE4D [cytosol] (Sus scrofa)
PDEdelta [cytosol] (Plasmodium falciparum)
PDEgamma [cytosol] (Plasmodium falciparum)
Pde4d [cytosol] (Mus musculus)
Pde4d [cytosol] (Rattus norvegicus)
Pde4 [cytosol] (Dictyostelium discoideum)
PDEbeta [cytosol] (Plasmodium falciparum)
pde-4 [cytosol] (Caenorhabditis elegans)
Cross References
RefSeq
XP_005248595.1
,
NP_006194.2
,
NP_001184150.1
,
XP_011541775.1
,
NP_001184148.1
,
XP_011541773.1
,
XP_016865055.1
,
NP_001184147.1
,
NP_001098101.1
,
NP_001184152.1
,
NP_001159371.1
,
NP_001184151.1
,
NP_001184149.1
ZINC - World Drugs
PDE4D_HUMAN
OpenTargets
ENSG00000113448
ZINC - FDA approved
PDE4D_HUMAN
ZINC - Substances
PDE4D_HUMAN
ZINC - Biogenic
PDE4D_HUMAN
ZINC target
Q08499
PRO
Q08499
PDB
6NJH
,
6KJZ
,
6F6U
,
6KK0
,
6FE7
,
2PW3
,
1OYN
,
6IMD
,
3G4G
,
1E9K
,
6AKR
,
3K4S
,
6BOJ
,
1XOM
,
6FEB
,
6IND
,
1MKD
,
6NJI
,
6NJJ
,
6FW3
,
6IMI
,
6F8V
,
6RCW
,
4W1O
,
6FT0
,
5LBO
,
6F8U
,
3V9B
,
5WH5
,
6INM
,
6F8T
,
6FET
,
5WQA
,
6F8R
,
3SL6
,
1TBB
,
3SL4
,
6FTA
,
3G4I
,
6HWO
,
1XOR
,
2FM5
,
1Y2B
,
1XOQ
,
5K1I
,
3IAK
,
6IMB
,
1XON
,
5TKB
,
1ZKN
,
3IAD
,
6IAG
,
4OGB
,
6FTW
,
1TB7
,
5K32
,
1Y2K
,
1Q9M
,
2FM0
,
1PTW
,
6INK
,
3G58
,
5WH6
,
6FDC
,
6IMO
,
2QYN
,
3G4L
,
4WCU
,
6FDI
,
1Y2E
,
3SL8
,
1Y2D
,
3G4K
,
6F8W
,
6IMR
,
6IBF
,
6F8X
,
6IMT
,
6IM6
,
3SL5
,
1Y2C
,
3SL3
ZINC - Investigational
PDE4D_HUMAN
ZINC - Metabolites
PDE4D_HUMAN
GeneCards
Q08499
HPA
ENSG00000113448-PDE4D
Ensembl
ENST00000502484
,
ENST00000340635
,
ENSP00000321739
,
ENSP00000425605
,
ENST00000317118
,
ENSP00000351800
,
ENST00000358923
,
ENST00000405755
,
ENSP00000425917
,
ENSP00000308485
,
ENSP00000353152
,
ENSG00000113448
,
ENST00000360047
,
ENST00000309641
,
ENST00000502575
,
ENSP00000384806
,
ENSP00000423094
,
ENST00000503258
,
ENST00000507116
,
ENSP00000424852
,
ENSP00000345502
Orphanet
21092
ZINC - Predictions - Purchasable
PDE4D_HUMAN
HMDB Protein
HMDBP00636
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32121 ARRB2
2
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [cytosol]
(R-HSA-416464)
0.564
2
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text