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PDE4A [cytosol]
Stable Identifier
R-HSA-52383
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cAMP-specific 3',5'-cyclic phosphodiesterase 4A , DPDE2, PDE46
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
PDE4A,C,D hydrolyse cAMP (Homo sapiens)
PDE4A,C,D [cytosol] (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
PDE4A binds PDE4A inhibitors (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
PDE4A:PDE4A inhibitors [cytosol] (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
PDE4A hydrolyses cAMP to AMP (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
PDE4A,C,D [cytosol] (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27815 PDE4A
Gene Names
PDE4A, DPDE2
Chain
chain:1-886
Reference Genes
BioGPS Gene:5141 PDE4A
COSMIC (genes):PDE4A PDE4A
CTD Gene:5141 PDE4A
dbSNP Gene:5141 PDE4A
ENSEMBL:ENSG00000065989 PDE4A
HGNC:8780 PDE4A
KEGG:hsa:5141 PDE4A
Monarch:5141 PDE4A
NCBI Gene:5141 PDE4A
OMIM:600126 PDE4A
UCSC:P27815 PDE4A
Reference Transcript
RefSeq:NM_006202.2 PDE4A
RefSeq:NM_001243121.1 PDE4A
RefSeq:XM_011528054.1 PDE4A
RefSeq:NM_001111307.1 PDE4A
RefSeq:NM_001111309.1 PDE4A
RefSeq:NM_001111308.1 PDE4A
Participates
as a member of
PDE4A,C,D [cytosol] (Homo sapiens)
as a component of
PDE4A:PDE4A inhibitors [cytosol] (Homo sapiens)
as an input of
PDE4A binds PDE4A inhibitors (Homo sapiens)
Inferred To
PDE4A [cytosol]
(Bos taurus)
PDE4A [cytosol]
(Caenorhabditis elegans)
PDE4A [cytosol]
(Canis familiaris)
PDE4A [cytosol]
(Dictyostelium discoideum)
PDE4A [cytosol]
(Drosophila melanogaster)
PDE4A [cytosol]
(Mus musculus)
PDE4A [cytosol]
(Plasmodium falciparum)
PDE4A [cytosol]
(Rattus norvegicus)
PDE4A [cytosol]
(Sus scrofa)
PDE4A [cytosol]
(Xenopus tropicalis)
Homologues of PDE4A [cytosol]
(Dictyostelium discoideum)
Homologues of PDE4A [cytosol]
(Plasmodium falciparum)
Cross References
Guide to Pharmacology - Targets
1300
ENSEMBL
ENST00000344979
,
ENSP00000341007
,
ENSP00000293683
,
ENST00000440014
,
ENST00000380702
,
ENST00000592685
,
ENSP00000468507
,
ENSP00000394754
,
ENST00000293683
,
ENSG00000065989
,
ENSP00000370078
OpenTargets
ENSG00000065989
ZINC - FDA approved
PDE4A_HUMAN
ZINC - Substances
PDE4A_HUMAN
ZINC target
P27815
PRO
P27815
PDB
2QYK
,
3TVX
,
3I8V
ZINC - Investigational
PDE4A_HUMAN
IntEnz
3.1.4.53
GeneCards
PDE4A
HPA
ENSG00000065989-PDE4A
Pharos - Targets
P27815
ZINC - Predictions - Purchasable
PDE4A_HUMAN
HMDB Protein
HMDBP00650
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75344 FKBP6
2
FKBP6 [nucleoplasm]
(R-HSA-912512)
FKBP6 [cytosol]
(R-HSA-5601923)
0.527
3
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