LCN2:2,5DHBA binds Fe3+

Stable Identifier
Reaction [binding]
Homo sapiens
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Neutrophil gelatinase associated lipocalin (LCN2, NGAL) is a member of the lipocalin superfamily that is involved in iron trafficking both in and out of cells. LCN2 binds iron via an association with 2,5 dihydroxybenzoic acid (2,5DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell via interacting with different receptors, depending on cellular requirement (Goetz et al. 2002, Devireddy et al. 2010). LCN2 is a potent bacteriostatic agent in iron limiting conditions therefore it is proposed that LCN2 participates in the antibacterial iron depletion strategy of the innate immune system (Flo et al. 2004).

Literature References
PubMed ID Title Journal Year
20550936 A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production

Goetz, DH, Hart, DO, Green, MR, Devireddy, LR

Cell 2010
12453412 The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition

Raymond, KN, Bluhm, ME, Goetz, DH, Strong, RK, Holmes, MA, Borregaard, N

Mol. Cell 2002
15531878 Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Aderem, A, Rodriguez, DJ, Flo, TH, Sato, S, Strong, RK, Akira, S, Holmes, MA, Smith, KD

Nature 2004
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