Reactome | LCN2:2,5DHBA binds Fe3+

LCN2:2,5DHBA binds Fe3+

Stable Identifier

R-HSA-5229273

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Neutrophil gelatinase associated lipocalin (LCN2, NGAL) is a member of the lipocalin superfamily that is involved in iron trafficking both in and out of cells. LCN2 binds iron via an association with 2,5 dihydroxybenzoic acid (2,5DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell via interacting with different receptors, depending on cellular requirement (Goetz et al. 2002, Devireddy et al. 2010). LCN2 is a potent bacteriostatic agent in iron limiting conditions therefore it is proposed that LCN2 participates in the antibacterial iron depletion strategy of the innate immune system (Flo et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
20550936	A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production Goetz, DH, Hart, DO, Green, MR, Devireddy, LR	Cell	2010
12453412	The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition Raymond, KN, Bluhm, ME, Goetz, DH, Strong, RK, Holmes, MA, Borregaard, N	Mol. Cell	2002
15531878	Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron Aderem, A, Rodriguez, DJ, Flo, TH, Sato, S, Strong, RK, Akira, S, Holmes, MA, Smith, KD	Nature	2004