Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MeR12-HIST1H2AB [nucleoplasm]
Stable Identifier
R-HSA-5229221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HIST1H2AB
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Homo sapiens)
Me2aR12-histone H2A, MeR12-histone H2A [nucleoplasm] (Homo sapiens)
MeR12-histone H2A [nucleoplasm] (Homo sapiens)
MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)
MeR12-HIST1H2AB [nucleoplasm] (Homo sapiens)
MeR12-histone H2A, Histone H2A [nucleoplasm] (Homo sapiens)
MeR12-histone H2A [nucleoplasm] (Homo sapiens)
MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)
MeR12-HIST1H2AB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04908 H2AC4
Gene Names
H2AC4, H2AFM, HIST1H2AB, H2AC8, H2AFA, HIST1H2AE
Chain
initiator methionine:, chain:2-130
Reference Genes
BioGPS Gene:3012 H2AC4
BioGPS Gene:8335 H2AC4
CTD Gene:3012 H2AC4
CTD Gene:8335 H2AC4
dbSNP Gene:3012 H2AC4
dbSNP Gene:8335 H2AC4
ENSEMBL:ENSG00000277075 HIST1H2AE
ENSEMBL:ENSG00000278463 HIST1H2AB
ENSEMBL_homo_sapiens_GENE:ENSG00000277075.3 H2AC4
ENSEMBL_homo_sapiens_GENE:ENSG00000278463.2 H2AC4
HGNC:4724 H2AC4
HGNC:4734 H2AC4
KEGG Gene (Homo sapiens):3012 H2AC4
KEGG Gene (Homo sapiens):8335 H2AC4
Monarch:3012 H2AC4
Monarch:8335 H2AC4
NCBI Gene:3012 H2AC4
NCBI Gene:8335 H2AC4
OMIM:602786 H2AC4
OMIM:602795 H2AC4
Reference Transcript
RefSeq:NM_003513.2 H2AC4
RefSeq:NM_021052.2 H2AC4
Other Identifiers
11731693_at
11731694_s_at
11741215_at
17005589
17016366
208569_PM_at
208569_at
214469_PM_at
214469_at
2899224
2899225
2899226
2946220
2946221
2946222
2946223
2946224
3012
35127_at
8117408
8124391
8335
A_14_P115530
A_23_P59045
A_24_P223384
GE504811
GE62562
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0006325
GO:0008285
GO:0030527
GO:0043226
GO:0043229
GO:0043505
GO:0046982
GO:0061644
GO:0070062
HMNXSV003010811
HMNXSV003012591
Hs.121017.0.S1_3p_at
ILMN_1753524
ILMN_1756849
M60752_at
PH_hs_0006702
PH_hs_0013174
PH_hs_0032313
TC06000173.hg
TC06001343.hg
Z83741_at
g4504246_3p_at
Participates
as a member of
MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
K63polyUb-HIST1H2AB [nucleoplasm]
Ub-HIST1H2AB [nucleoplasm]
Ack6-HIST1H2AB [nucleoplasm]
Me2aR30-HIST1H2AB [nucleoplasm]
MeR30-HIST1H2AB [nucleoplasm]
Me2aR4-HIST1H2AB [nucleoplasm]
MeR4-HIST1H2AB [nucleoplasm]
Me2sR4-HIST1H2AB [nucleoplasm]
Me2aR12-HIST1H2AB [nucleoplasm]
HIST1H2AB [extracellular region]
Ack-HIST1H2AB [nucleoplasm]
HIST1H2AB [nucleoplasm]
Inferred To
LOC100485548 [nucleoplasm]
(Xenopus tropicalis)
LOC100487632 [nucleoplasm]
(Xenopus tropicalis)
LOC116411633 [nucleoplasm]
(Xenopus tropicalis)
Hist1h2ap [nucleoplasm]
(Mus musculus)
his-35 [nucleoplasm]
(Caenorhabditis elegans)
HTA1 [nucleoplasm]
(Saccharomyces cerevisiae)
HTA2 [nucleoplasm]
(Saccharomyces cerevisiae)
H2Av2 [nucleoplasm]
(Dictyostelium discoideum)
His2A:CG33862 [nucleoplasm]
(Drosophila melanogaster)
MeR12-HIST1H2AB [nucleoplasm]
(Gallus gallus)
MeR12-HIST1H2AB [nucleoplasm]
(Plasmodium falciparum)
H2ac10 [nucleoplasm]
(Rattus norvegicus)
Hist1h2ao [nucleoplasm]
(Mus musculus)
hta1 [nucleoplasm]
(Schizosaccharomyces pombe)
Hist1h2af [nucleoplasm]
(Mus musculus)
H2ac12 [nucleoplasm]
(Mus musculus)
his-65 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of MeR12-HIST1H2AB [nucleoplasm]
(Caenorhabditis elegans)
Homologues of MeR12-HIST1H2AB [nucleoplasm]
(Danio rerio)
Homologues of MeR12-HIST1H2AB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of MeR12-HIST1H2AB [nucleoplasm]
(Drosophila melanogaster)
Homologues of MeR12-HIST1H2AB [nucleoplasm]
(Mus musculus)
Homologues of MeR12-HIST1H2AB [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of MeR12-HIST1H2AB [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of MeR12-HIST1H2AB [nucleoplasm]
(Xenopus tropicalis)
hta2 [nucleoplasm]
(Schizosaccharomyces pombe)
h2ac16 [nucleoplasm]
(Xenopus tropicalis)
H2AC4 [nucleoplasm]
(Bos taurus)
H2AC4 [nucleoplasm]
(Canis familiaris)
H2AC4 [nucleoplasm]
(Sus scrofa)
LOC116407737 [nucleoplasm]
(Xenopus tropicalis)
LOC100487067 [nucleoplasm]
(Xenopus tropicalis)
h2ax1 [nucleoplasm]
(Danio rerio)
H2ac4 [nucleoplasm]
(Mus musculus)
zgc:56685 [nucleoplasm]
(Danio rerio)
H2ac6 [nucleoplasm]
(Mus musculus)
Hist1h2an [nucleoplasm]
(Mus musculus)
H2ac15 [nucleoplasm]
(Mus musculus)
H2AX [nucleoplasm]
(Dictyostelium discoideum)
H2Av3 [nucleoplasm]
(Dictyostelium discoideum)
htas-1 [nucleoplasm]
(Caenorhabditis elegans)
H2Av1 [nucleoplasm]
(Dictyostelium discoideum)
H2ac8 [nucleoplasm]
(Mus musculus)
H2ac11 [nucleoplasm]
(Mus musculus)
LOC101732059 [nucleoplasm]
(Xenopus tropicalis)
His2A:CG33859 [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
omega-N-methyl-L-arginine at 12
Coordinate
12
PsiMod Name
omega-N-methyl-L-arginine
PsiMod Definition
A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.
Cross References
RefSeq
NP_066390.1
,
NP_003504.2
OpenTargets
ENSG00000278463
GeneCards
P04908
HPA
ENSG00000278463-H2AC4
,
ENSG00000277075-H2AC8
Ensembl
ENSG00000277075
,
ENSG00000278463
,
ENST00000615868
,
ENSP00000303373
,
ENST00000303910
,
ENSP00000483842
PRO
P04908
Pharos - Targets
P04908
HMDB Protein
HMDBP07727
PDB
8UQE
,
8JLB
,
8HE5
,
5B31
,
7D20
,
5ZBX
,
8JLA
,
8SNA
,
7PEW
,
7XX7
,
7PF6
,
6T7C
,
7K63
,
7V9K
,
7VA4
,
7DBP
,
5CPI
,
7V9C
,
6V92
,
8UPF
,
3W99
,
3AZE
,
6J4Z
,
5AV9
,
2RVQ
,
6A5L
,
3AZH
,
7XT7
,
8OSL
,
8SMZ
,
5Y0C
,
7CCQ
,
8JH4
,
5B0Z
,
8HR1
,
8KB5
,
8TXV
,
8SMY
,
8OTT
,
5XF5
,
7XSZ
,
7WBW
,
7SCY
,
7PFA
,
8JLD
,
7D1Z
,
8JH2
,
6L9H
,
8OTS
,
7XCR
,
7XVL
,
6T93
,
6R8Z
,
6M3V
,
7VZ4
,
6R8Y
,
3AZN
,
7W9V
,
3W97
,
8IEJ
,
3AZI
,
8IHL
,
5X7X
,
7PFC
,
5AVB
,
6YOV
,
6L9Z
,
6A5O
,
6L4A
,
8HAN
,
8SN6
,
5AY8
,
6INQ
,
8TXW
,
6E0P
,
3AV1
,
7WBV
,
8WG5
,
6HTS
,
8OSJ
,
3AFA
,
6J4W
,
5B32
,
6M44
,
7V9J
,
3AZM
,
5B24
,
6LA2
,
8SN4
,
6IPU
,
3WTP
,
3X1S
,
7PEU
,
7K5X
,
7PFF
,
7CCR
,
8SN8
,
7XX5
,
5GSE
,
6R93
,
6L49
,
6V2K
,
7PFD
,
8UQB
,
6ACL
,
5AVC
,
6A5P
,
8HAG
,
8I17
,
6AEE
,
8JH3
,
7PF2
,
7PFX
,
5Y0D
,
8U14
,
3AN2
,
7XD1
,
8U13
,
8OSK
,
8SMX
,
6A5R
,
6T7A
,
5AV5
,
6T7D
,
6LA8
,
7PFT
,
7Y7I
,
6J4X
,
7XX6
,
8JHG
,
7BWD
,
3A6N
,
6R94
,
5B40
,
5B2I
,
6HKT
,
7K61
,
8IEG
,
5CPJ
,
7V99
,
3X1V
,
7BXT
,
7LYC
,
7PFE
,
7V96
,
7XSX
,
6T7B
,
2CV5
,
8HAM
,
5GTC
,
8HAL
,
7LYA
,
7PF0
,
3AZL
,
6A5T
,
7K5Y
,
3AYW
,
7XZZ
,
8G57
,
8HAJ
,
7PEX
,
3W96
,
4YM5
,
8UQD
,
5XF3
,
8SN3
,
7XZY
,
7XSE
,
8SN2
,
7PF5
,
6JXD
,
8H0W
,
7PEZ
,
8UQA
,
3AZK
,
7C0M
,
7PFV
,
6J50
,
6R90
,
5AV6
,
5JRG
,
5GXQ
,
4YM6
,
6JR0
,
7XZX
,
7XTD
,
7K60
,
7XTI
,
6LE9
,
6BUZ
,
5CPK
,
8GRM
,
7PFW
,
7LYB
,
5B2J
,
7PEY
,
7XVM
,
7NL0
,
7PFU
,
8UQ9
,
8SN5
,
3AV2
,
7WBX
,
7SCZ
,
6A5U
,
6O1D
,
6USJ
,
8HAK
,
7XD0
,
6R91
,
8SMW
,
7XCT
,
8JL9
,
6JR1
,
8UQC
,
5Z23
,
8HAI
,
3AZF
,
7PEV
,
6LA9
,
6LER
,
3WKJ
,
8TXX
,
6E0C
,
7PET
,
5XF4
,
8SN1
,
8H0V
,
8SN0
,
7V9S
,
6T90
,
7VCL
,
6IR9
,
8UQ8
,
6R92
,
6IQ4
,
6J4Y
,
7Y00
,
6KXV
,
7V90
,
5AV8
,
7COW
,
4Z5T
,
7PF4
,
8SN9
,
6LAB
,
3W98
,
6J51
,
6KE9
,
8HAH
,
3AZG
,
8SN7
,
7BY0
,
8HQY
,
3AZJ
,
6T79
,
7ZI4
,
5B0Y
,
7PF3
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.874
12
UniProt:Q16695 H3-4
3
HIST3H3 [nucleoplasm]
(R-HSA-181914)
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
0.589
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text