PRMT6 methylates histone H2A arginine-30 (H2AR29)

Stable Identifier
R-HSA-5229203
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PRMT6 methylates histone H2A at arginine-30 (H2AR29). Dimethylation of H2AR29 is specifically enriched at genes repressed by PRMT6, indicating a role for this mark in gene silencing (Waldmann et al. 2011).

Literature References
PubMed ID Title Journal Year
21774791 Methylation of H2AR29 is a novel repressive PRMT6 target

Waldmann, T, Izzo, A, Kamieniarz, K, Richter, F, Vogler, C, Sarg, B, Lindner, H, Young, NL, Mittler, G, Garcia, BA, Schneider, R

Epigenetics Chromatin 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-arginine N-methyltransferase activity of PRMT6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed