PRMT6 methylates histone H2A arginine-30 (H2AR29)

Stable Identifier
R-HSA-5229203
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PRMT6 methylates histone H2A at arginine-30 (H2AR29). Dimethylation of H2AR29 is specifically enriched at genes repressed by PRMT6, indicating a role for this mark in gene silencing (Waldmann et al. 2011).

Literature References
PubMed ID Title Journal Year
21774791 Methylation of H2AR29 is a novel repressive PRMT6 target

Waldmann, T, Izzo, A, Kamieniarz, K, Richter, F, Vogler, C, Sarg, B, Lindner, H, Young, NL, Mittler, G, Garcia, BA, Schneider, R

Epigenetics Chromatin 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-arginine N-methyltransferase activity of PRMT6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created