PRMT6 methylates histone H2A arginine-30 (H2AR29)

Stable Identifier
R-HSA-5229203
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PRMT6 methylates histone H2A at arginine-30 (H2AR29). Dimethylation of H2AR29 is specifically enriched at genes repressed by PRMT6, indicating a role for this mark in gene silencing (Waldmann et al. 2011).

Literature References
PubMed ID Title Journal Year
21774791 Methylation of H2AR29 is a novel repressive PRMT6 target

Waldmann, T, Izzo, A, Kamieniarz, K, Richter, F, Vogler, C, Sarg, B, Lindner, H, Young, NL, Mittler, G, Garcia, BA, Schneider, R

Epigenetics Chromatin 2011
Participants
Participates
Catalyst Activity

protein-arginine N-methyltransferase activity of PRMT6 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!