PRMT6 methylates histone H2A arginine-30 (H2AR29)

Stable Identifier
R-HSA-5229203
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PRMT6 methylates histone H2A arginine-30 (H2AR29)
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PRMT6 methylates histone H2A at arginine-30 (H2AR29). Dimethylation of H2AR29 is specifically enriched at genes repressed by PRMT6, indicating a role for this mark in gene silencing (Waldmann et al. 2011).
Literature References
PubMed ID Title Journal Year
21774791 Methylation of H2AR29 is a novel repressive PRMT6 target

Waldmann, T, Izzo, A, Kamieniarz, K, Richter, F, Vogler, C, Sarg, B, Lindner, H, Young, NL, Mittler, G, Garcia, BA, Schneider, R

Epigenetics Chromatin 2011
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Catalyst Activity

protein-arginine N-methyltransferase activity of PRMT6 [nucleoplasm]

Physical Entity
PRMT6 [nucleoplasm] (Homo sapiens)
Activity
protein-arginine N-methyltransferase activity (GO:0016274)
Orthologous Events
PRMT6 methylates histone H2A arginine-30 (H2AR29) (Bos taurus)
PRMT6 methylates histone H2A arginine-30 (H2AR29) (Canis familiaris)
PRMT6 methylates histone H2A arginine-30 (H2AR29) (Danio rerio)
PRMT6 methylates histone H2A arginine-30 (H2AR29) (Dictyostelium discoideum)
PRMT6 methylates histone H2A arginine-30 (H2AR29) (Mus musculus)
PRMT6 methylates histone H2A arginine-30 (H2AR29) (Rattus norvegicus)
PRMT6 methylates histone H2A arginine-30 (H2AR29) (Sus scrofa)
Authored
Jupe, S  (2013-03-12)
Reviewed
Guccione, E  (2014-05-09)
Fischle, W  (2014-07-23)
Created
Jupe, S  (2014-01-17)
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