Reactome | CARM1 methylates arginine-27 of histone H3 (H3R26)

CARM1 methylates arginine-27 of histone H3 (H3R26)

Stable Identifier

R-HSA-5229010

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CARM1 methylates arginine-27 of histone H3

ReviewStatus

5/5

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CARM1 methylates arginine-27 of histone H3 (H3R26)

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Coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) methylates histone H3 at arginine-18 (H3R17) (Ma et al. 2001, Bauer et al. 2002) and to a lesser extent arginine-27 (H3R26) (Schurter et al. 2001, Bauer et al. 2002). In vitro it can also methylate arginine-3, and one or more of four arginines (129/130/132/135) at the C-terminus (Schurter et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11341840	Methylation of histone H3 by coactivator-associated arginine methyltransferase 1 Koh, SS, Stallcup, MR, Henschen-Edman, A, Hanson, BL, Harp, JM, Chen, D, Aswad, DW, Schurter, BT, Mackay, DR, Bunick, GJ	Biochemistry	2001
11751582	Methylation at arginine 17 of histone H3 is linked to gene activation Bauer, UM, Nielsen, SJ, Daujat, S, Nightingale, K, Kouzarides, T	EMBO Rep.	2002