CARM1 methylates arginine-27 of histone H3 (H3R26)

Stable Identifier
R-HSA-5229010
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CARM1 methylates arginine-27 of histone H3
ReviewStatus
5/5
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Coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) methylates histone H3 at arginine-18 (H3R17) (Ma et al. 2001, Bauer et al. 2002) and to a lesser extent arginine-27 (H3R26) (Schurter et al. 2001, Bauer et al. 2002). In vitro it can also methylate arginine-3, and one or more of four arginines (129/130/132/135) at the C-terminus (Schurter et al. 2001).
Literature References
PubMed ID Title Journal Year
11341840 Methylation of histone H3 by coactivator-associated arginine methyltransferase 1

Koh, SS, Stallcup, MR, Henschen-Edman, A, Hanson, BL, Harp, JM, Chen, D, Aswad, DW, Schurter, BT, Mackay, DR, Bunick, GJ

Biochemistry 2001
11751582 Methylation at arginine 17 of histone H3 is linked to gene activation

Bauer, UM, Nielsen, SJ, Daujat, S, Nightingale, K, Kouzarides, T

EMBO Rep. 2002
Participants
Participates
Catalyst Activity

protein-arginine N-methyltransferase activity of CARM1 [nucleoplasm]

Orthologous Events
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