Reactome | ROCK1,ROCK2 are activated

ROCK1,ROCK2 are activated

Stable Identifier

R-HSA-5228992

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RHOA propagates downstream signals by binding to effector proteins such as Rho-associated, coiled-coil containing protein kinases (ROCKs). ROCKs consist of an amino-terminal kinase domain, followed by a Rho-binding domain (RBD) and a carboxy terminal cysteine-rich domain (CRD) located within the pleckstrin homology (PH) motif. RHOA:GTP interacts with the RBD domain and activates the phosphotransferase activity (Ishizaki et al. 1996, Amano et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
8617235	The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase Saito, Y, Fujita, A, Narumiya, S, Okawa, K, Iwamatsu, A, Morii, N, Fujisawa, K, Kakizuka, A, Ishizaki, T, Watanabe, N, Maekawa, M	EMBO J	1996