Retrograde transport of internalized TeNT HC:LC:gangliosides

Stable Identifier
R-HSA-5228408
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
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Vesicles containing ganglioside-bound tetanus toxin disulfide-bonded heavy chain - light chain dimer (TeNT HC:LC) are transported in a retrograde fashion away from the target cell synapse where they were formed into the cell body (Lalli et al. 2003).

Literature References
PubMed ID Title Journal Year
13678859 The journey of tetanus and botulinum neurotoxins in neurons

Lalli, G, Bohnert, S, Deinhardt, K, Verastegui, C, Schiavo, G

Trends Microbiol 2003
Participants
Participant Of
Disease
Name Identifier Synonyms
tetanus 11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Authored
Reviewed
Created
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