Retrograde transport of internalized tetX HC:LC:gangliosides

Stable Identifier
R-HSA-5228408
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
clathrin-coated endocytic vesicle membrane, endocytic vesicle membrane
ReviewStatus
5/5
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Retrograde transport of internalized tetX HC:LC:gangliosides
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Vesicles containing ganglioside-bound tetanus toxin disulfide-bonded heavy chain - light chain dimer (tetX HC:LC) are transported in a retrograde fashion away from the target cell synapse where they were formed into the cell body (Lalli et al. 2003).
Literature References
PubMed ID Title Journal Year
13678859 The journey of tetanus and botulinum neurotoxins in neurons

Verastegui, C, Schiavo, G, Lalli, G, Deinhardt, K, Bohnert, S

Trends Microbiol 2003
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tetanus DOID:11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Authored
D'Eustachio, P  (2014-02-11)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-11)
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