Reactome | ADD1:ADD2 binds DMTN

ADD1:ADD2 binds DMTN

Stable Identifier

R-HSA-5226979

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Alpha-adducin (ADD1 aka ADDA) (Joshi et al. 1991) is a ubiquitously expressed, membrane-cytoskeletal protein that can promote the assembly of the spectrin-actin network. It is functional in a heterodimeric form, in complex with either a beta (ADD2 aka ADDB) (Khan et al. 2008) or a gamma (ADD3 aka ADDL) subunit (Citterio et al. 2003). Either complex is able to bind dematin (DMTN) (Azim et al. 1995), a membrane-cytoskeletal protein that can induce F-actin bundles formation and stabilization. It can also bind the erythrocyte membrane glucose transporter 1 (SLC2A1 aka GLUT1), and hence stabilise the spectrin-actin network to the erythrocytic plasma membrane (Khan et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
7615546	Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily Azim, AC, Knoll, JH, Beggs, AH, Chishti, AH	J. Biol. Chem.	1995
18347014	Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1 Khan, AA, Hanada, T, Mohseni, M, Jeong, JJ, Zeng, L, Gaetani, M, Li, D, Reed, BC, Speicher, DW, Chishti, AH	J. Biol. Chem.	2008
1840603	Primary structure and domain organization of human alpha and beta adducin Joshi, R, Gilligan, DM, Otto, E, McLaughlin, T, Bennett, V	J. Cell Biol.	1991
12951058	Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants Citterio, L, Tizzoni, L, Catalano, M, Zerbini, G, Bianchi, G, Barlassina, C	Biochem. Biophys. Res. Commun.	2003