ABCE1 binds RNASEL, inhibiting it

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
2-5A-dependent ribonuclease (RNASEL) is an endoribonuclease that is activated in the interferon (IFN) antiviral response. Its anti-viral effects are probably a combination of induction of apoptosis, cleavage of viral mRNA and induction of other anti-viral genes. ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase L inhibitor, RLI) directly interacts with RNASEL and inhibits its endoribonuclease activity, thus antagonising the anti-viral effect of the IFN-regulated 2-5A/RNase L pathway (Martinand et al. 1998, Martinand et al. 1999, Le Roy et al. 2001).
Literature References
PubMed ID Title Journal Year
9660177 RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells

Salehzada, T, Martinand, C, Bisbal, C, Lebleu, B, Silhol, M

Eur. J. Biochem. 1998
11585831 The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells

Salehzada, T, Martinand, C, Bisbal, C, Lebleu, B, Le Roy, F, Silhol, M

J. Biol. Chem. 2001
9847332 RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells

Salehzada, T, Martinand, C, Bisbal, C, Lebleu, B, Silhol, M, Montavon, C

J. Virol. 1999
Event Information
Orthologous Events
Cite Us!