TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine

Stable Identifier
R-HSA-5220952
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As inferred from mouse, TET1, TET2, and TET3 each oxidize 5-formylcytosine (5-fC) in DNA using molecular oxygen and 2-oxoglutarate to yield 5-carboxylcytosine (5-caC).
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
chromosomal 5-methylcytosine DNA demethylation, oxidation pathway (0141167)
Catalyst Activity

5-methylcytosine dioxygenase activity of TET1,2,3 [nucleoplasm]

Physical Entity
TET1,2,3 [nucleoplasm] (Homo sapiens)
Activity
5-methylcytosine dioxygenase activity (GO:0070579)
Inferred From
Tet1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine (Mus musculus)
Authored
May, B  (2013-12-29)
Reviewed
Mukherji, M  (2014-02-21)
Pfeifer, GP  (2014-01-29)
Created
May, B  (2013-12-30)
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