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p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
Stable Identifier
R-HSA-5218908
Type
Polymer
Species
Homo sapiens
Compartment
cytosol
Synonyms
RIP1:RIP3 oligomer, RIPK1:RIPK3 oligomer
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)
SARS-CoV-1 3a:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)
3a tetramer:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
3a tetramer:(RIPK1:RIPK3) oligomer [lysosomal membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
SARS-CoV-1 3a oligomerizes (Homo sapiens)
3a tetramer:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
SARS-CoV-1 3a:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1-mediated effects on programmed cell death (Homo sapiens)
SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)
SARS-CoV-1 3a:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)
3a tetramer:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
3a tetramer:(RIPK1:RIPK3) oligomer [lysosomal membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
SARS-CoV-1 3a oligomerizes (Homo sapiens)
3a tetramer:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
SARS-CoV-1 3a:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
MLKL binds PIPs (Homo sapiens)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
MLKL oligomerizes (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
RIPK3 phosphorylates MLKL (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
ATP binds MLKL (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
ITCH polyubiquitinates MLKL at K50 (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xK63PolyUb-K50,p-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
MLKL binds FLOT1, FLOT2 (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
MLKL binds IP4, IP5 and IP6 (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
MLKL binds ITCH (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
MLKL binds PDCD6IP and SDCBP (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
TRP channels (Homo sapiens)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
Participants
repeated unit
p-S166-RIPK1:p-S199,227-RIPK3 [cytosol]
(Homo sapiens)
Participates
as an input of
SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)
RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
as a component of
SARS-CoV-1 3a:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
3a tetramer:(RIPK1:RIPK3) oligomer [lysosomal membrane] (Homo sapiens)
3a tetramer:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xK63PolyUb-K50,p-T357,S358-MLKL [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
as an output of
RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Homo sapiens)
Inferred To
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Canis familiaris)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Dictyostelium discoideum)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Gallus gallus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Sus scrofa)
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Xenopus tropicalis)
Cross References
ChEBI
36080
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