VAV exchanges GTP for GDP on RAC1, activating it

Stable Identifier
R-HSA-5218850
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Tyrosine-phosphorylated VAVs act as guanine nucleotide exchange factors (GEFs) for RAC1, catalysing the exchange of bound GDP for GTP. RAC1 is a key regulator for actin cytoskeleton and cell migration and is also a critical component of endothelial NADPH oxidase (Wittmann et al. 2003, Tan et al. 2008, Ushio–Fukai 2007, Ushio–Fukai et al. 2002). Activated RAC1 then stimulates actin polymerisation to form lamellipodia through a number of proteins such as WASP-family veroprilin homologous protein (WAV). WAVE proteins stimulate the formation of a branched actin network by binding to the p21 subunit of the ARP2/3 nucleating complex, which is located on the sides of the pre-existing filaments.

Literature References
PubMed ID Title Journal Year
17686471 VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

Garrett, TA, Van Buul, JD, Burridge, K

Exp. Cell Res. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-VAV family:PIP3:RAC1:GDP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created