VAV exchanges GTP for GDP on RAC1, activating it

Stable Identifier
R-HSA-5218850
Type
Reaction
Species
Homo sapiens
Compartment
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Tyrosine-phosphorylated VAVs act as guanine nucleotide exchange factors (GEFs) for RAC1, catalysing the exchange of bound GDP for GTP. RAC1 is a key regulator for actin cytoskeleton and cell migration and is also a critical component of endothelial NADPH oxidase (Wittmann et al. 2003, Tan et al. 2008, Ushio–Fukai 2007, Ushio–Fukai et al. 2002). Activated RAC1 then stimulates actin polymerisation to form lamellipodia through a number of proteins such as WASP-family veroprilin homologous protein (WAV). WAVE proteins stimulate the formation of a branched actin network by binding to the p21 subunit of the ARP2/3 nucleating complex, which is located on the sides of the pre-existing filaments.

Literature References
PubMed ID Title Journal Year
17686471 VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

Burridge, K, Van Buul, JD, Garrett, TA

Exp. Cell Res. 2007
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-VAV family:PIP3:RAC1:GDP [plasma membrane]

Orthologous Events
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