Reactome | PAK2 binds NCK

PAK2 binds NCK

Stable Identifier

R-HSA-5218847

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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P21-activated kinase 2 (PAK2) is an effector of GTP-bound CDC42. It associates with NCK and possibly links activated CDC42 to the SAPK2/p38 module (Lamalice et al. 2006, Zhao et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
16966330	Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF Lamalice, L, Houle, F, Huot, J	J. Biol. Chem.	2006

Participants

Input

Output

VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

VEGFA-VEGFR2 Pathway

Orthologous Events

PAK2 binds NCK (Bos taurus)

PAK2 binds NCK (Canis familiaris)

PAK2 binds NCK (Danio rerio)

PAK2 binds NCK (Mus musculus)

PAK2 binds NCK (Rattus norvegicus)

PAK2 binds NCK (Sus scrofa)

PAK2 binds NCK (Xenopus tropicalis)

Authored

Garapati, P V (2013-08-30)

Reviewed

Welsh, M (2014-05-12)

Berger, P (2014-05-12)

Ballmer-Hofer, K (2014-05-12)

Created

Garapati, P V (2013-12-19)