Reactome | PXN binds p-6Y,S732-PTK2

PXN binds p-6Y,S732-PTK2

Stable Identifier

R-HSA-5218838

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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General

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Paxillin (PXN) is a multidomain scaffolding protein localized primarily in focal adhesions. It binds with focal adhesion kinase (FAK1, also known as PTK2) and is recruited to the focal adhesions. VEGF induced a quick and marked increase in the recruitment of both paxillin and vinculin to FAK (Abedi & Zachary 1997).

Literature References

PubMed ID	Title	Journal	Year
9182576	Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells Abedi, H, Zachary, I	J. Biol. Chem.	1997

Participants

Input

Output

VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

VEGFA-VEGFR2 Pathway

Orthologous Events

PXN binds p-6Y,S732-PTK2 (Bos taurus)

PXN binds p-6Y,S732-PTK2 (Canis familiaris)

PXN binds p-6Y,S732-PTK2 (Danio rerio)

PXN binds p-6Y,S732-PTK2 (Mus musculus)

PXN binds p-6Y,S732-PTK2 (Rattus norvegicus)

PXN binds p-6Y,S732-PTK2 (Xenopus tropicalis)

Authored

Garapati, P V (2013-08-30)

Reviewed

Welsh, M (2014-05-12)

Berger, P (2014-05-12)

Ballmer-Hofer, K (2014-05-12)

Created

Garapati, P V (2013-12-19)