Proline tyrosine kinase 2-beta (PTK2B), also known as cell adhesion kinase-beta or related adhesion focal tyrosine kinase, is a nonreceptor protein-tyrosine kinase closely related to focal adhesion kinase (FAK1) that couples receptors, including integrins, with a variety of downstream effectors such as small G proteins belonging to the Ras and Rho families, mitogen-activated protein kinases, protein kinase C, and inositol phosphate metabolism (Avraham et al. 2000). PYK2B has been shown to play a critical role in the adhesion and migration of many cell types. PYK2B has been shown to localise to integrin and has been demonstrated to associate directly with integrin beta3 cytoplasmic tail (Butler & Blystone 2005, Duong & Rodan 2000, Le Boeuf et al. 2006).