PTK2beta binds alphaVbeta3

Stable Identifier
R-HSA-5218836
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Proline tyrosine kinase 2-beta (PTK2B), also known as cell adhesion kinase-beta or related adhesion focal tyrosine kinase, is a nonreceptor protein-tyrosine kinase closely related to focal adhesion kinase (FAK1) that couples receptors, including integrins, with a variety of downstream effectors such as small G proteins belonging to the Ras and Rho families, mitogen-activated protein kinases, protein kinase C, and inositol phosphate metabolism (Avraham et al. 2000). PYK2B has been shown to play a critical role in the adhesion and migration of many cell types. PYK2B has been shown to localise to integrin and has been demonstrated to associate directly with integrin beta3 cytoplasmic tail (Butler & Blystone 2005, Duong & Rodan 2000, Le Boeuf et al. 2006).

Literature References
PubMed ID Title Journal Year
15695828 Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2

Butler, B, Blystone, SD

J. Biol. Chem. 2005
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