SRC-1 phosphorylates PTK2-beta

Stable Identifier
R-HSA-5218830
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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SRC-1 phosphorylates PTK2-beta
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Proline tyrosine kinase 2-beta (PTK2B/PYK2) is rapidly tyrosine phosphorylated on Y402 through Src-kinases in response to ligation of integrin beta3.

Literature References
PubMed ID Title Journal Year
15695828 Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2

Butler, B, Blystone, SD

J. Biol. Chem. 2005
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]

Physical Entity
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SRC-1 phosphorylates PTK2-beta (Bos taurus)
SRC-1 phosphorylates PTK2-beta (Canis familiaris)
SRC-1 phosphorylates PTK2-beta (Gallus gallus)
SRC-1 phosphorylates PTK2-beta (Mus musculus)
SRC-1 phosphorylates PTK2-beta (Rattus norvegicus)
SRC-1 phosphorylates PTK2-beta (Sus scrofa)
SRC-1 phosphorylates PTK2-beta (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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