Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732

Stable Identifier
R-HSA-5218826
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
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Activated ROCK directly phosphorylates FAK1 on S732. This phosphorylation induces a conformational change that is necessary to trigger the phosphorylation of FAK on Y407 (Le Bouef et al. 2006).

Literature References
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]
Physical Entity
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Danio rerio)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Rattus norvegicus)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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