Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732

Stable Identifier
R-HSA-5218826
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated ROCK directly phosphorylates FAK1 on S732. This phosphorylation induces a conformational change that is necessary to trigger the phosphorylation of FAK on Y407 (Le Bouef et al. 2006).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created