Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732

Stable Identifier
R-HSA-5218826
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated ROCK directly phosphorylates FAK1 on S732. This phosphorylation induces a conformational change that is necessary to trigger the phosphorylation of FAK on Y407 (Le Bouef et al. 2006).

Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!