CRK binds BCAR1 and or PXN

Stable Identifier
R-HSA-5218822
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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CRK binds BCAR1 and or PXN
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CRK (CT10 Regulator of Kinase) is composed of one SH2 and one or two SH3 domains. This adaptor protein binds with phosphorylated tyrosine motifs found in proteins involved in cell spreading, actin reorganisation, and cell migration. Paxillin (PAX) and p130CAS are the two major focal adhesion components that binds with CRK to form multiprotein signaling complexes and regulate cell migration (Klemke et al. 1998, Valles et al. 2004, Lamorte et al. 2003).
Literature References
PubMed ID Title Journal Year
9472046 CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

Cheresh, DA, Klemke, RL, Molander, R, Brooks, PC, Vuori, K, Leng, J

J. Cell Biol. 1998
15308668 Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells

Boyer, B, Vallés, AM, Beuvin, M

J. Biol. Chem. 2004
Participants
Input
Output
Participates
as an event of
Orthologous Events
CRK binds BCAR1 and or PXN (Bos taurus)
CRK binds BCAR1 and or PXN (Canis familiaris)
CRK binds BCAR1 and or PXN (Gallus gallus)
CRK binds BCAR1 and or PXN (Mus musculus)
CRK binds BCAR1 and or PXN (Rattus norvegicus)
CRK binds BCAR1 and or PXN (Sus scrofa)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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