FYN phosphorylates PAK2

Stable Identifier
R-HSA-5218812
Type
Reaction
Species
Homo sapiens
Compartment
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PAK2 activity via GTPases can be strongly potentiated by concurrent stimulation of cellular tyrosine kinase activity. FYN may be involved in this potentiation by phosphorylating Y130 in the N-terminal regulatory domain leading to a robust enhancement of the catalytic activity of PAK2 (Renkema et al. 2002).

Literature References
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane]

Orthologous Events
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