DOCK180:ELMO binds CRK

Stable Identifier
R-HSA-5218811
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The SH3 domain of CRK interacts constitutively with proline rich motifs present in Dedicator of cytokinesis (DOCK180), an exchange factor for RAC1. Unlike many GEFs, DOCK180 does not contain a conserved Dbl homology (DH) domain. Instead, it has a DHR2 or DOCKER domain capable of loading RAC1 with GTP (Brugnera et al 2002). Binding of DOCK180 to RAC1 alone is insufficient for GTP loading, a DOCK180-ELMO interaction is required. Engulfment and cell motility protein 1 (ELMO1) or ELMO2 form a complex with DOCK180 which functions as a bipartite GEF to optimally activate RAC1 (Gumienny et al 2001, Brugnera et al 2002, Birge et al. 2009).

Literature References
PubMed ID Title Journal Year
15308668 Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells

Vall├ęs, AM, Beuvin, M, Boyer, B

J. Biol. Chem. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created