HSP90AA1 binds p-6Y-VEGFR2

Stable Identifier
R-HSA-5218643
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Heat-shock protein of 90 kDa (HSP90) a molecular chaperone, associates with VEGFR2 in response to VEGF. The last 130 amino acids of VEGFR2 C-terminal portion are involved in the association of VEGFR2 with HSP90. HSP90 associated with VEGFR2 is involved in regulating the activity of a Rho-associated protein kinase (ROCK) that is required to phosphorylate FAK on residue S732 (Le Bouef et al. 2004, 2006).

Literature References
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Participant Of
Orthologous Events
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Created