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HSP90AA1 binds p-6Y-VEGFR2
Stable Identifier
R-HSA-5218643
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)
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Heat-shock protein of 90 kDa (HSP90) a molecular chaperone, associates with VEGFR2 in response to VEGF. The last 130 amino acids of VEGFR2 C-terminal portion are involved in the association of VEGFR2 with HSP90. HSP90 associated with VEGFR2 is involved in regulating the activity of a Rho-associated protein kinase (ROCK) that is required to phosphorylate FAK on residue S732 (Le Bouef et al. 2004, 2006).
Literature References
PubMed ID
Title
Journal
Year
15247219
Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities
Houle, F
,
Le Boeuf, F
,
Huot, J
J. Biol. Chem.
2004
Participants
Input
HSP90AA1 [cytosol]
(Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane]
(Homo sapiens)
Output
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
VEGFA-VEGFR2 Pathway (Homo sapiens)
Orthologous Events
HSP90AA1 binds p-6Y-VEGFR2 (Bos taurus)
HSP90AA1 binds p-6Y-VEGFR2 (Canis familiaris)
HSP90AA1 binds p-6Y-VEGFR2 (Gallus gallus)
HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)
HSP90AA1 binds p-6Y-VEGFR2 (Rattus norvegicus)
HSP90AA1 binds p-6Y-VEGFR2 (Sus scrofa)
Authored
Garapati, P V (2013-08-30)
Reviewed
Ballmer-Hofer, K (2014-05-12)
Welsh, M (2014-05-12)
Berger, P (2014-05-12)
Created
Garapati, P V (2013-12-19)
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