Reactome | SRC-1 phosphorylates p-Y397-PTK2

SRC-1 phosphorylates p-Y397-PTK2

Stable Identifier

R-HSA-5218640

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Src family kinases (SFKs) induce transphosphorylation of tyrosyl residues Y576, Y577, Y861 and Y925. Phosphorylation of Y576 and Y577 within the catalytic domain confers maximal FAK1 enzymatic activity and signaling in response to adhesion (Calalb et al. 1995, Brunton et al. 2005). Y576 and Y861 are both phosphorylated in a Src-dependent manner in response to VEGF (Abu-Ghazaleh et al. 2001, Le Boeuf et al. 2006, 2004). Phosphorylation of FAK on Y861 contributes to the recruitment of vinculin to FAK1 (Le Boeuf et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
11696015	Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells Kabir, J, Lobo, M, Jia, H, Zachary, I, Abu-Ghazaleh, R	Biochem. J.	2001