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NPC1

Stable Identifier
R-HSA-5216153
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Niemann-Pick C1 protein, NPC1_HUMAN
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:O15118 NPC1
Gene Names
NPC1
Chain
signal peptide:1-22, chain:23-1278
Reference Genes
BioGPS Gene:4864 NPC1
COSMIC (genes):NPC1 NPC1
CTD Gene:4864 NPC1
dbSNP Gene:4864 NPC1
ENSEMBL:ENSG00000141458 NPC1
HGNC:7897 NPC1
KEGG Gene (Homo sapiens):hsa:4864 NPC1
Monarch:4864 NPC1
NCBI Gene:4864 NPC1
OMIM:607623 NPC1
UCSC:O15118 NPC1
Reference Transcript
Other Identifiers
0006650563
11743916_a_at
11746723_a_at
16854268
202679_at
26618
37047_at
3GKH
3GKI
3GKJ
3JD8
4864
5F18
5F1B
5HNS
5I31
5JNX
5KWY
70132
8022531
980_at
A_23_P107587
AAB63982
AAD48006
AAF28875
AAH63302
AAK25791
AC010853
AC026634
AF002020
AF002020_at
AF157365
AF157366
AF157367
AF157368
AF157369
AF157370
AF157371
AF157372
AF157373
AF157374
AF157375
AF157376
AF157377
AF157378
AF157379
AF338230
AH009108
AK293779
BAG57194
BC063302
CAB070132
CCDS11878
ENSG00000141458
ENSP00000269228
ENST00000269228
EntrezGene:4864
g4557802_3p_at
GE54045
GO:0001618
GO:0003674
GO:0004871
GO:0004872
GO:0004888
GO:0005319
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005794
GO:0005886
GO:0005887
GO:0005975
GO:0006464
GO:0006486
GO:0006629
GO:0006810
GO:0006897
GO:0006914
GO:0007034
GO:0007041
GO:0007165
GO:0007628
GO:0008150
GO:0008202
GO:0008203
GO:0008206
GO:0008219
GO:0008289
GO:0009056
GO:0009058
GO:0015248
GO:0015485
GO:0016020
GO:0016021
GO:0016032
GO:0016192
GO:0016242
GO:0030301
GO:0031410
GO:0031579
GO:0031902
GO:0031982
GO:0033344
GO:0034383
GO:0042493
GO:0042592
GO:0042632
GO:0043226
GO:0044281
GO:0044403
GO:0045121
GO:0046686
GO:0046718
GO:0048471
GO:0060548
GO:0061024
GO:0070062
GO:0071383
GO:0071404
GO:0090150
GO:2000189
HGNC:7897
HPA026618
Hs.715623
ILMN_1713505
IPR000731
IPR003392
IPR004765
IPR032190
MIM:257220
MIM:607623
NM_000271
NP_000262
NPC1
NPC1-201
PF02460
PF12349
PF16414
PH_hs_0024642
TC18000413.hg
uc002kum.5
UPI000013D80F
XM_005258277
XM_005258278
XM_005258279
XM_006722479
XM_011526015
XM_017025784
XM_017025785
XM_017025786
XM_017025787
XP_005258334
XP_005258335
XP_005258336
XP_006722542
XP_011524317
XP_016881273
XP_016881274
XP_016881275
XP_016881276
Participant Of
input
hasComponent
output
Inferred To
Homologues of NPC1 [lysosomal membrane] (Arabidopsis thaliana)
Homologues of NPC1 [lysosomal membrane] (Danio rerio)
Homologues of NPC1 [lysosomal membrane] (Dictyostelium discoideum)
Homologues of NPC1 [lysosomal membrane] (Drosophila melanogaster)
Homologues of NPC1 [lysosomal membrane] (Oryza sativa)
Homologues of NPC1 [lysosomal membrane] (Rattus norvegicus)
NPC1 [lysosomal membrane] (Arabidopsis thaliana)
NPC1 [lysosomal membrane] (Bos taurus)
NPC1 [lysosomal membrane] (Canis familiaris)
NPC1 [lysosomal membrane] (Danio rerio)
NPC1 [lysosomal membrane] (Dictyostelium discoideum)
NPC1 [lysosomal membrane] (Drosophila melanogaster)
NPC1 [lysosomal membrane] (Gallus gallus)
NPC1 [lysosomal membrane] (Mus musculus)
NPC1 [lysosomal membrane] (Oryza sativa)
NPC1 [lysosomal membrane] (Rattus norvegicus)
NPC1 [lysosomal membrane] (Saccharomyces cerevisiae)
NPC1 [lysosomal membrane] (Sus scrofa)
NPC1 [lysosomal membrane] (Taeniopygia guttata)
NPC1 [lysosomal membrane] (Xenopus tropicalis)
Cross References
RefSeq
GeneCards
ZINC - Substances
DOCK Blaster
ZINC target
PRO
ZINC - Predictions - Purchasable
Orphanet
PDB
Interactors (5)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 cholesterol [ChEBI:16113]  20 0.733 7
 UniProt:X5HMX4 X5HMX4      0.558 3
 25-hydroxycholesterol [ChEBI:42977]  4 0.558 2
 UniProt:P61916 NPC2  3 0.524 2
 UniProt:Q03135 CAV1  5 0.463 3