Reactome | PON1 [extracellular region]

PON1 [extracellular region]

Stable Identifier

R-HSA-5216077

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Serum paraoxonase/arylesterase 1, PON1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonic acid metabolism (Homo sapiens)
      - Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
        
        PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)
        
        PON1,2,3:2xCa2+ dimers [extracellular region] (Homo sapiens)
        
        PON1:2xCa2+ dimer [extracellular region] (Homo sapiens)
        
        PON1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P27169 PON1

Gene Names

PON1, PON

Chain

initiator methionine:, chain:2-355, signal peptide:2-

Reference Genes

BioGPS Gene:5444 PON1

COSMIC (genes):PON1 PON1

CTD Gene:5444 PON1

dbSNP Gene:5444 PON1

ENSEMBL:ENSG00000005421 PON1

ENSEMBL_homo_sapiens_GENE:ENSG00000005421.9 PON1

HGNC:9204 PON1

KEGG Gene (Homo sapiens):5444 PON1

Monarch:5444 PON1

NCBI Gene:5444 PON1

UCSC:P27169 PON1

Reference Transcript

RefSeq:NM_000446.5 PON1

Other Identifiers

11736569_at

11759206_at

17059895

206344_PM_at

206344_at

206345_PM_s_at

206345_s_at

3061941

3061943

3061944

3061945

3061946

3061951

3061952

3061953

3061955

3061956

3061957

3061958

3061960

3061962

3061963

38861_at

5444

8141052

A_23_P168598

A_24_P337846

A_33_P3340615

GE60430

GO:0003824

GO:0004063

GO:0004064

GO:0005509

GO:0005543

GO:0005576

GO:0005615

GO:0005783

GO:0005789

GO:0006629

GO:0008203

GO:0008289

GO:0009636

GO:0010875

GO:0016787

GO:0019439

GO:0032411

GO:0034364

GO:0034366

GO:0042803

GO:0043226

GO:0046395

GO:0046434

GO:0046470

GO:0046872

GO:0051099

GO:0070062

GO:0072562

GO:0102007

HMNXSV003014898

ILMN_1662944

PH_hs_0023442

TC07003363.hg

Z70723_at

g1280040_3p_at

g4505950_3p_a_at

Participates

as a component of

PON1:2xCa2+ dimer [extracellular region] (Homo sapiens)

Other forms of this molecule

PON1 [endoplasmic reticulum membrane]

Inferred To

PON1 [extracellular region] (Bos taurus)

PON1 [extracellular region] (Caenorhabditis elegans)

PON1 [extracellular region] (Canis familiaris)

PON1 [extracellular region] (Danio rerio)

PON1 [extracellular region] (Gallus gallus)

PON1 [extracellular region] (Mus musculus)

PON1 [extracellular region] (Rattus norvegicus)

PON1 [extracellular region] (Sus scrofa)

PON1 [extracellular region] (Xenopus tropicalis)

poml-3 [extracellular region] (Caenorhabditis elegans)

mec-6 [extracellular region] (Caenorhabditis elegans)

Homologues of PON1 [extracellular region] (Caenorhabditis elegans)

Homologues of PON1 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_000437.3

Guide to Pharmacology - Targets

3052

OpenTargets

ENSG00000005421

ZINC target

P27169

PRO

P27169

PDB

1V04

IntEnz

3.1.1.2

HPA

ENSG00000005421-PON1

GeneCards

P27169

Ensembl

ENSG00000005421, ENSP00000222381, ENST00000222381

Pharos - Targets

P27169

Orphanet

19320

HMDB Protein

HMDBP00091

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NBN7 RDH13	1	RDH13 [mitochondrial inner membrane] (R-HSA-2980995)	0.527	3