Reactome | MRS2 [mitochondrial inner membrane]

MRS2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5216072

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Magnesium transporter MRS2 homolog, mitochondrial, MRS2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q92633 LPAR1

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External Reference Information

External Reference

UniProt:Q9HD23 MRS2

Gene Names

MRS2, HPT, MRS2L

Chain

transit peptide:1-49, chain:50-443

Reference Genes

BioGPS Gene:57380 MRS2

COSMIC (genes):MRS2 MRS2

CTD Gene:57380 MRS2

dbSNP Gene:57380 MRS2

ENSEMBL:ENSG00000124532 MRS2

ENSEMBL_homo_sapiens_GENE:ENSG00000124532.15 MRS2

HGNC:13785 MRS2

KEGG Gene (Homo sapiens):57380 MRS2

Monarch:57380 MRS2

NCBI Gene:57380 MRS2

OMIM:619307 MRS2

UCSC:Q9HD23 MRS2

Reference Transcript

Other Identifiers

11725681_s_at

11725682_x_at

11725683_at

11745838_a_at

11752747_a_at

11752748_x_at

11759577_at

17005348

218536_PM_at

218536_at

218538_PM_s_at

218538_s_at

228542_PM_at

228542_at

2898453

2898454

2898455

2898456

2898459

2898462

2898463

2898464

2898465

2898470

2898471

2898472

2898473

2898474

2898479

2898480

2898481

2898482

2898483

2898484

2898485

2898486

2898487

2898488

2898490

2898492

34687_at

57056_s_at

57380

76369_at

76371_g_at

8117194

92044_at

92045_g_at

A_14_P111162

A_23_P111373

A_33_P3255814

A_33_P3372281

GE54473

GE80457

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0006089

GO:0006811

GO:0015095

GO:0016020

GO:0043226

GO:0045016

GO:0055085

HMNXSV003021031

HMNXSV003053298

Hs.30057.0.S2_3p_at

Hs.30057.2.S1_3p_at

ILMN_1778677

PH_hs_0022611

TC06000144.hg

g10190701_3p_a_at

Inferred To

MRS2 [mitochondrial inner membrane] (Bos taurus)

MRS2 [mitochondrial inner membrane] (Canis familiaris)

MRS2 [mitochondrial inner membrane] (Dictyostelium discoideum)

MRS2 [mitochondrial inner membrane] (Gallus gallus)

MRS2 [mitochondrial inner membrane] (Plasmodium falciparum)

MRS2 [mitochondrial inner membrane] (Sus scrofa)

Mrs2 [mitochondrial inner membrane] (Mus musculus)

Mrs2 [mitochondrial inner membrane] (Rattus norvegicus)

mrs2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

mrs2 [mitochondrial inner membrane] (Xenopus tropicalis)

MFM1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Homologues of MRS2 [mitochondrial inner membrane] (Plasmodium falciparum)

Cross References

RefSeq

NP_001273195.1, NP_001273193.1, NP_065713.1, NP_001273194.1

OpenTargets

ENSG00000124532

HPA

ENSG00000124532-MRS2

GeneCards

Q9HD23

Ensembl

ENSP00000399585, ENST00000378353, ENST00000378386, ENST00000443868, ENSG00000124532, ENSP00000367637, ENSP00000367604

PRO

Q9HD23

Pharos - Targets

Q9HD23

HMDB Protein

HMDBP08762

PDB

8TUP, 8IP5, 8IP3, 8IP6, 8TUL, 8IP4

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:Q9NWT8 AURKAIP1	1	AURKAIP1 [mitochondrial inner membrane] (R-HSA-5368203)	0.527	2
UniProt:Q9P0J7 KCMF1	2	KCMF1 [extracellular region] (R-HSA-6806467) KCMF1 [ficolin-1-rich granule lumen] (R-HSA-6801525)	0.527	2
UniProt:Q9H0U9 TSYL1			0.527	2
UniProt:Q92633 LPAR1	1	LPAR1 [plasma membrane] (R-HSA-419354)	0.527	2
UniProt:Q8N5V2 NGEF	2	NGEF [cytosol] (R-HSA-3006800) p-Y179-NGEF [cytosol] (R-HSA-3928441)	0.527	3
UniProt:Q96JJ6 JPH4			0.527	2
UniProt:Q99689 FEZ1			0.527	2
UniProt:Q9Y6E2 5MP1			0.527	3
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.527	3
UniProt:Q8TCT7 SPPL2B	1	SPPL2B [plasma membrane] (R-HSA-8863116)	0.527	3
UniProt:Q9NZE8 MRPL35	1	MRPL35 [mitochondrial inner membrane] (R-HSA-5368235)	0.527	2
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.527	2
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.527	3
UniProt:Q6ZT07 TBCD9			0.527	2
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.527	2
UniProt:O60443 GSDME	18	GSDME(1-270) G199E [cytosol] (R-HSA-9710427) GSDME(1-270) R48I [cytosol] (R-HSA-9710474) GSDME(1-270) I137T [cytosol] (R-HSA-9710473) GSDME W46* [cytosol] (R-HSA-9711042) GSDME(1-270) D18V [cytosol] (R-HSA-9710466) GSDME(1-270) D14Y [cytosol] (R-HSA-9710450) GSDME(1-270) P212L [cytosol] (R-HSA-9710487) GSDME(1-270) W44C [cytosol] (R-HSA-9710470) GSDME(1-270) I217N [cytosol] (R-HSA-9710437) GSDME E210* [cytosol] (R-HSA-9710420) GSDME(1-270) [cytosol] (R-HSA-9647689) GSDME [cytosol] (R-HSA-9647620) GSDME (271-496) [cytosol] (R-HSA-9647615) GSDME(1-270) E177V [cytosol] (R-HSA-9710403) GSDME(1-270) T196M [cytosol] (R-HSA-9710429) GSDME(1-270) G17D [cytosol] (R-HSA-9710478) GSDME(1-270) E134A [cytosol] (R-HSA-9710410) GSDME(1-270) N24D [cytosol] (R-HSA-9710404)	0.527	2
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.527	3
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.527	2
UniProt:Q6ZMH5 SLC39A5	1	SLC39A5 [plasma membrane] (R-HSA-442360)	0.527	2
UniProt:P04618 rev	3	REV (P04618) protein [extracellular region] (R-HIV-174998) REV (P04618) protein [nucleoplasm] (R-HIV-175380) REV (P04618) protein [cytosol] (R-HIV-173267)	0.462	2

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